Isatuximab in Combination With Chemotherapy in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia

PHASE2TerminatedINTERVENTIONAL
Enrollment

67

Participants

Timeline

Start Date

August 6, 2019

Primary Completion Date

September 12, 2022

Study Completion Date

May 26, 2023

Conditions
Acute Lymphoblastic LeukemiaAcute Myeloid Leukemia
Interventions
DRUG

Isatuximab

Pharmaceutical form: Concentrate for solution for intravenous infusion Route of administration: Intravenous

DRUG

Dexamethasone or equivalent

Pharmaceutical form: Solution for injection or tablet Route of administration: Intravenous or oral

DRUG

Fludarabine

Pharmaceutical form: Solution for injection Route of administration: Intravenous

DRUG

Cytarabine

Pharmaceutical form: Solution for injection Route of administration: Intravenous

DRUG

Liposomal daunorubicin

Pharmaceutical form: Solution for injection Route of administration: Intravenous

DRUG

Daunorubicin (nonliposomal)

Pharmaceutical form: Solution for injection Route of administration: Intravenous infusion

DRUG

Idarubicin

Pharmaceutical form: Solution for injection Route of administration: Intravenous

DRUG

Filgrastim or equivalent

Pharmaceutical form: Solution for injection Route of administration: Intravenous

DRUG

Mitoxantrone

Pharmaceutical form: Solution for injection Route of administration: Intravenous

DRUG

Doxorubicin

Pharmaceutical form: Solution for injection Route of administration: Intravenous

DRUG

Vincristine

Pharmaceutical form: Solution for injection Route of administration: Intravenous

DRUG

Pegaspargase (PEG) Asparaginase

Pharmaceutical form: Solution for injection Route of administration: Intravenous infusion

DRUG

Cyclophosphamide

Pharmaceutical form: Solution for injection Route of administration: Intravenous

DRUG

Etoposide

Pharmaceutical form: Solution for injection Route of administration: Intravenous infusion

DRUG

Methotrexate

Pharmaceutical form: Solution for injection Route of administration: Intravenous infusion

DRUG

L - Asparginase

Pharmaceutical form: Solution for injection Route of administration: Intramuscular

DRUG

Hydroxyurea

Pharmaceutical form: Solution for injection Route of administration: PO

DRUG

L - Asparaginase (Erwinase)

Pharmaceutical form: Solution for injection Route of administration: Intramuscular

Trial Locations (41)

34

Investigational Site Number :6040002, Lima

1094

Investigational Site Number :3480002, Budapest

2100

Investigational Site Number :2080001, Copenhagen

5021

Investigational Site Number :5780001, Bergen

10126

Investigational Site Number :3800003, Turin

16147

Investigational Site Number :3800002, Genoa

20246

Investigational Site Number :2760003, Hamburg

20900

Investigational Site Number :3800001, Monza

37126

Investigational Site Number :3800005, Verona

37203

Sarah Cannon Research Institute-Site Number:8400001, Nashville

48149

Investigational Site Number :2760006, Münster

59037

Investigational Site Number :2500002, Lille

64460

Investigational Site Number :4840001, Monterrey

69008

Investigational Site Number :2500003, Lyon

75235

Children's Medical Center of Dallas-Site Number:8400002, Dallas

75571

Investigational Site Number :2500001, Paris

75935

Investigational Site Number :2500004, Paris

76140

Investigational Site Number :4840005, Col. Rancho Menchaca

91054

Investigational Site Number :2760005, Erlangen

C1181ACH

Investigational Site Number :0320002, CABA

C1425DUC

Investigational Site Number :0320006, Capital Federal

C1118AAT

Investigational Site Number :0320005, Buenos Aires

C1245AAM

Investigational Site Number :0320004, Buenos Aires

80250-060

Investigational Site Number :0760013, Curitiba

81520-060

Investigational Site Number :0760006, Curitiba

90035 003

Investigational Site Number :0760007, Porto Alegre

17210-070

Investigational Site Number :0760010, Jaú

14048-900

Investigational Site Number :0760009, Ribeirão Preto

08270-070

Investigational Site Number :0760001, São Paulo

4023-062

Investigational Site Number :0760004, São Paulo

115 27

Investigational Site Number :3000001, Athens

3584 CS

Investigational Site Number :5280001, Utrecht

0342

Investigational Site Number :5780002, Oslo

Unknown

Investigational Site Number :6040001, Arequipa

3000-602

Investigational Site Number :6200002, Coimbra

1099-023

Investigational Site Number :6200001, Lisbon

4200-162

Investigational Site Number :6200003, Porto

03080

Investigational Site Number :4100001, Seoul

06351

Investigational Site Number :4100002, Seoul

137-701

Investigational Site Number :4100004, Seoul

416 85

Investigational Site Number :7520001, Gothenburg

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Sanofi

INDUSTRY

NCT03860844 - Isatuximab in Combination With Chemotherapy in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia | Biotech Hunter | Biotech Hunter