Testing the Combination of the Anti-cancer Drugs Copanlisib, Olaparib, and MEDI4736 (Durvalumab) in Patients With Advanced Solid Tumors With Selected Mutations

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

39

Participants

Timeline

Start Date

November 21, 2019

Primary Completion Date

July 29, 2024

Study Completion Date

September 24, 2026

Conditions
Advanced Malignant Solid NeoplasmMetastatic Malignant Solid NeoplasmUnresectable Malignant Solid Neoplasm
Interventions
PROCEDURE

Biopsy Procedure

Undergo tumor biopsy

PROCEDURE

Biospecimen Collection

Undergo collection of blood samples

PROCEDURE

Computed Tomography

Undergo CT

DRUG

Copanlisib Hydrochloride

Given IV

BIOLOGICAL

Durvalumab

Given IV

PROCEDURE

Echocardiography Test

Undergo ECHO

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Olaparib

Given PO

PROCEDURE

X-Ray Imaging

Undergo x-ray

Trial Locations (17)

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

53792

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

60611

Northwestern University, Chicago

77030

M D Anderson Cancer Center, Houston

78229

University of Texas Health Science Center at San Antonio, San Antonio

78712

University of Texas at Austin, Austin

80045

UCHealth University of Colorado Hospital, Aurora

90020

Keck Medicine of USC Koreatown, Los Angeles

90033

Los Angeles General Medical Center, Los Angeles

USC / Norris Comprehensive Cancer Center, Los Angeles

90621

Keck Medicine of USC Buena Park, Buena Park

91105

Keck Medical Center of USC Pasadena, Pasadena

92663

USC Norris Oncology/Hematology-Newport Beach, Newport Beach

02115

Brigham and Women's Hospital, Boston

02215

Beth Israel Deaconess Medical Center, Boston

Dana-Farber Cancer Institute, Boston

77555-0565

University of Texas Medical Branch, Galveston

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH