GP Vs PF As Induction Chemotherapy Combined with CCRT for Locoregionally Advanced Nasopharyngeal Carcinoma

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

468

Participants

Timeline

Start Date

April 3, 2019

Primary Completion Date

August 31, 2026

Study Completion Date

December 31, 2028

Conditions
Nasopharyngeal CarcinomaNasopharyngeal NeoplasmsNasopharyngeal DiseasesHead and Neck Neoplasm
Interventions
DRUG

gemcitabine and cisplatin

Patients receive gemcitabine (1000 mg/m² d1,8) and cisplatin (80mg/m² d1) every 3 weeks for 3 cycles before concurrent chemoradiotherapy.

DRUG

cisplatin and fluorouracil

Patients receive fluorouracil (800mg/m2 d1-5) and cisplatin (80mg/m² d1) every 3 weeks for 3 cycles before concurrent chemoradiotherapy.

RADIATION

IMRT

Intensity modulated-radiotherapy (IMRT) is given as 30~33 fraction with five daily fractions per week for 6-7 weeks to a total dose of 68~70 Gy to the primary tumor

DRUG

cisplatin

IMRT concurrently with cisplatin 100 mg/m² every 3 weeks for 2 cycles.

Trial Locations (1)

510060

Sun Yat-sen University Cancer Center, Guangzhou

All Listed Sponsors
collaborator

First Affiliated Hospital, Sun Yat-Sen University

OTHER

collaborator

Guangdong Provincial People's Hospital, China

UNKNOWN

collaborator

Affiliated Cancer Hospital & Institute of Guangzhou Medical University

OTHER

lead

Sun Yat-sen University

OTHER