Study to Compare the Combination of Ribociclib Plus Goserelin Acetate With Hormonal Therapy Versus Combination Chemotherapy in Premenopausal or Perimenopausal Patients With Advanced or Metastatic Breast Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

222

Participants

Timeline

Start Date

February 25, 2019

Primary Completion Date

April 12, 2022

Study Completion Date

May 10, 2023

Conditions
Breast Cancer
Interventions
COMBINATION_PRODUCT

Docetaxel / Capecitabine

"Docetaxel (IV Infusion) / Capecitabine (Tablets for oral use):~Docetaxel once, on day 1 of the 3-weeks cycle. Capecitabine twice daily, on Days 1 to 14, followed by a 1-week rest period, in 3 weeks cycle.~Docetaxel (60 - 75 mg/m²)/capecitabine (1600 - 2500 mg/m²/day)"

COMBINATION_PRODUCT

Capecitabine / Vinorelbine

"Capecitabine (Tablets for oral use) / Vinorelbine (Capsule for Oral use/IV infusion ).~Capecitabine twice daily on day 1 to 14, followed by a 1-week rest period, in 3 weeks cycle.~Vinorelbine, once, on Day 1 and Day 8 in 3 weeks cycles.~Capecitabine (1600 - 2500 mg/m2/day)/vinorelbine (60 to 80 mg/m2/day \[oral\] or (25 to 30 mg/m2 \[IV infusion\]"

COMBINATION_PRODUCT

Paclitaxel / Gemcitabine

"Paclitaxel (IV Infusion) / Gemcitabine (IV Infusion):~Paclitaxel via 3-hour intravenous (IV) infusion on Day 1 in 3-weeks cycles, OR Paclitaxel via 1 hour intravenous (IV) infusion on Day 1 and day 8- in 3-weeks cycles.~Gemcitabine at via 30 minute IV infusion on Day 1 and Day 8 in 3 weeks cycles.~Paclitaxel (175 mg/m2) (on Day 1 in 3-weeks cycles)/ gemcitabine (1000 - 1250 mg/m2)~OR~Paclitaxel (80 - 90 mg/m2) (on Day 1 and Day 8 in 3-weeks cycles) / gemcitabine (800 - 1250 mg/m2)"

DRUG

Ribociclib

Dose: 600 mg (200 mg \* 3) Days 1 to 21 of each 28 day cycle Tablets for oral use

DRUG

Letrozole OR Anastrozole

"Letrozole:~Dose: 2.5 mg All days of every cycle without interruption). Tablets for oral use~Anastrozole:~dose: 1 mg All days of every cycle without interruption. Tablets for oral use~The NSAI (letrozole or anastrozole) will be decided by the treating physician."

DRUG

Goserelin

"Dose: 3.6 mg Day 1 of each 28 day cycle (regardless of ribociclib treatment cycle) with an administration window of + 3 days.~Subcutaneous implant"

Trial Locations (50)

114

Novartis Investigative Site, Taipei

652

Novartis Investigative Site, Saida

1434

Novartis Investigative Site, Tripoli

4091

Novartis Investigative Site, Durban

10002

Novartis Investigative Site, Taipei

10310

Novartis Investigative Site, Bangkok

10400

Novartis Investigative Site, Bangkok

10449

Novartis Investigative Site, Taipei

10990

Novartis Investigative Site, Pulau Pinang

11211

Novartis Investigative Site, Riyadh

11217

Novartis Investigative Site, Taipei

11451

Novartis Investigative Site, Giza

11566

Novartis Investigative Site, Cairo

11941

Novartis Investigative Site, Amman

12655

Novartis Investigative Site, Cairo

33305

Novartis Investigative Site, Taoyuan District

34381

Novartis Investigative Site, Istanbul

35040

Novartis Investigative Site, Izmir

40447

Novartis Investigative Site, Taichung

44280

Novartis Investigative Site, Malatya

50200

Novartis Investigative Site, Chiang Mai

50586

Novartis Investigative Site, Kuala Lumpur

70403

Novartis Investigative Site, Tainan City

81100

Novartis Investigative Site, Johor Bahru

83301

Novartis Investigative Site, Kaohsiung City

88586

Novartis Investigative Site, Kota Kinabalu

90110

Novartis Investigative Site, Songkhla

93586

Novartis Investigative Site, Kuching

100000

Novartis Investigative Site, Hanoi

110029

Novartis Investigative Site, New Delhi

111123

Novartis Investigative Site, Moscow

115478

Novartis Investigative Site, Moscow

168583

Novartis Investigative Site, Singapore

188770

Novartis Investigative Site, Singapore

196603

Novartis Investigative Site, Pushkin Saint Petersburg

197758

Novartis Investigative Site, Saint Petersburg

258499

Novartis Investigative Site, Singapore

411004

Novartis Investigative Site, Pune

500082

Novartis Investigative Site, Hyderabad

700099

Novartis Investigative Site, Kolkata

3247511

Novartis Investigative Site, Cairo

560 095

Novartis Investigative Site, Bangalore

400 012

Novartis Investigative Site, Mumbai

1107 2020

Novartis Investigative Site, Beirut

0002

Novartis Investigative Site, Pretoria

0081

Novartis Investigative Site, Pretoria

06560

Novartis Investigative Site, Cankaya Ankara

06010

Novartis Investigative Site, Kecioren Ankara

06520

Novartis Investigative Site, Ankara

07059

Novartis Investigative Site, Antalya

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY