A Study to Evaluate Safety, PK, Efficacy of TLC590 for Postsurgical Pain Management Following Bunionectomy

TLC590, a sustained-release formulation of the local anesthetics with lipid-based excipients

Local infiltration of Naropin to produce anesthesia for surgery and analgesia in postoperative pain management. 50 mg (0.5%, 10 mL)

Normal Saline (0.9% sodium chloride, 10ml)

Bupivacaine 50 mg (0.5%, 10 mL)