Radiotherapy, Carboplatin/Paclitaxel and Nivolumab for High Risk HPV-related Head and Neck Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

26

Participants

Timeline

Start Date

September 5, 2019

Primary Completion Date

June 11, 2024

Study Completion Date

June 11, 2024

Conditions
Oropharynx Squamous Cell Carcinoma
Interventions
DRUG

Nivolumab

Given intravenously (IV), 240 mg every 2 weeks for 4 doses concurrent with radiation therapy (RT). Following completion of RT, 480 mg given every 4 weeks for 4 doses.

DRUG

Carboplatin

Given IV once per week during radiation therapy (AUC=1).

DRUG

Paclitaxel

Given IV once per week during radiation therapy (30mg/m\^2)

RADIATION

Radiation Therapy

Given 5 days/week for a total of 35 doses (70 gray total).

Trial Locations (1)

48109

University of Michigan Rogel Cancer Center, Ann Arbor

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

University of Michigan Rogel Cancer Center

OTHER

NCT03829722 - Radiotherapy, Carboplatin/Paclitaxel and Nivolumab for High Risk HPV-related Head and Neck Cancer | Biotech Hunter | Biotech Hunter