Neoadjuvant Letrozole and Palbociclib in Patients With Stage II-IIIB Breast Cancer, HR+, HER2 -

PHASE2CompletedINTERVENTIONAL
Enrollment

66

Participants

Timeline

Start Date

May 7, 2019

Primary Completion Date

July 30, 2019

Study Completion Date

December 31, 2019

Conditions
Breast Cancer
Interventions
DRUG

Pre treatment Recurrence Score:18-25 Letrozole + Palbociclib

Letrozole(2,5 mg/day during 28 days of each Cycle) + Palbociclib(125mg/day during 21 days of each cycle of 28 days) as neoadjuvant treatment during 6 cycles before surgery of Breast Cancer for patients with pre-treatment recurrence Score of 18-25

DRUG

Pre treatment Recurrence Score:26-100 Letrozole + Palbociclib

Letrozole(2,5 mg/day during 28 days of each Cycle) + Palbociclib(125mg/day during 21 days of each cycle of 28 days) as neoadjuvant treatment during 6 cycles before surgery of Breast Cancer for patients with pre-treatment recurrence Score of 26-100

Trial Locations (18)

28034

Hospital Ramón y Cajal, Madrid

46009

Instituto Valenciano de Oncologia, Valencia

Unknown

Hospital da Luz, Lisbon

Hospital Fernando Fonseca, Lisbon

Portuguese Institute of Oncology of Oporto, Porto

Hospital de Jaén, Jaén

Complejo Hospitalario Universitario A Coruña (CHUAC), A Coruña

H. Vall Hebrón, Barcelona

Hospital del Mar, Barcelona

Hospital Reina Sofia, Córdoba

Onkologikoa, Donostia / San Sebastian

Hospital Arnau de Vilanova, Lleida

Hospital Universitario Virgen del Rocío, Seville

Hospital Arnau de Vilanova de Valencia, Valencia

Hospital Clinico Universitario de Valencia, Valencia

Hospital Miguel Servet, Zaragoza

08916

ICO Badalona, Badalona

08007

ICO l'Hospitalet, L'Hospitalet de Llobregat

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Pfizer

INDUSTRY

lead

MedSIR

OTHER

NCT03819010 - Neoadjuvant Letrozole and Palbociclib in Patients With Stage II-IIIB Breast Cancer, HR+, HER2 - | Biotech Hunter | Biotech Hunter