Lung Transplant Plasmapheresis/Belatacept/Carfilzomib for Antibody Mediated Rejection and Desensitization

PHASE2WithdrawnINTERVENTIONAL
0
Timeline

Start Date

May 1, 2019

Primary Completion Date

August 1, 2020

Study Completion Date

October 30, 2020

Conditions
Lung Transplant RejectionAntibody-mediated Rejection
Interventions
DRUG

Belatacept

"Initial phase: 10 mg/kg on days 0 and 4, and again at weeks 2 and 4. Maintenance phase: 10 mg/kg every month beginning 4 weeks after completion of the initial phase.~No dosage adjustments required for renal or hepatic impairment. No known drug interactions for usual post-transplant medication regimen."

DRUG

Carfilzomib

20mg/m2 Plasmapheresis

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Duke University

OTHER

NCT03805178 - Lung Transplant Plasmapheresis/Belatacept/Carfilzomib for Antibody Mediated Rejection and Desensitization | Biotech Hunter | Biotech Hunter