NCT03802630 - Assessing the Efficacy and Safety of Brolucizumab Versus Aflibercept in Patients With Visual Impairment Due to Macular Edema Secondary to Branch Retinal Vein Occlusion | Biotech Hunter

Enrollment

450

Participants

Timeline

Start Date

July 2, 2019

Primary Completion Date

July 26, 2021

Study Completion Date

July 26, 2021

Conditions

Branch Retinal Vein Occlusion

Interventions

DRUG

Brolucizumab 6 mg

Solution for injection (intravitreal use)

DRUG

Aflibercept 2 mg

Solution for injection (Intravitreal use)

OTHER

Sham injection

"Empty sterile syringe without a needle administered as a sham injection for masking purposes.~From Week 24 to Week 72 inclusive, a sham treatment was performed to maintain subject masking in case treatment with brolucizumab or aflibercept was not deemed necessary by the investigator."

Trial Locations (102)

1006

Novartis Investigative Site, Lausanne

2100

Novartis Investigative Site, Copenhagen

4102

Novartis Investigative Site, Binningen

10002

Novartis Investigative Site, Taipei

12808

Novartis Investigative Site, Prague

15146

Novartis Investigative Site, Monroeville

15706

Novartis Investigative Site, Santiago de Compostela

21034

Novartis Investigative Site, Dijon

28040

Novartis Investigative Site, Madrid

28210

Novartis Investigative Site, Charlotte

28803

Novartis Investigative Site, Asheville

32503

Novartis Investigative Site, Pensacola

33000

Novartis Investigative Site, Bordeaux

33100

Novartis Investigative Site, Udine

33711

Novartis Investigative Site, St. Petersburg

37075

Novartis Investigative Site, Göttingen

37540

Novartis Investigative Site, Saint-Cyr-sur-Loire

40212

Novartis Investigative Site, Düsseldorf

41009

Novartis Investigative Site, Seville

44122

Novartis Investigative Site, Cleveland

46280

Novartis Investigative Site, Indianapolis

47150

Novartis Investigative Site, New Albany

48145

Novartis Investigative Site, Münster

50006

Novartis Investigative Site, Changhua

53105

Novartis Investigative Site, Bonn

55131

Novartis Investigative Site, Mainz

56124

Novartis Investigative Site, Pisa

66211

Novartis Investigative Site, Leawood

66215

Novartis Investigative Site, Lenexa

67000

Novartis Investigative Site, Strasbourg

67063

Novartis Investigative Site, Ludwigshafen

75010

Novartis Investigative Site, Paris

75015

Novartis Investigative Site, Paris

76012

Novartis Investigative Site, Arlington

77025

Novartis Investigative Site, Houston

77030

Novartis Investigative Site, Houston

77401

Novartis Investigative Site, Bellaire

78240

Novartis Investigative Site, San Antonio

78731

Novartis Investigative Site, Austin

78750

Novartis Investigative Site, Austin

79106

Novartis Investigative Site, Freiburg im Breisgau

79606

Novartis Investigative Site, Abilene

80909

Novartis Investigative Site, Colorado Springs

85020

Novartis Investigative Site, Phoenix

85107

Novartis Investigative Site, Bratislava

89075

Novartis Investigative Site, Ulm

89502

Novartis Investigative Site, Reno

91031

Novartis Investigative Site, Jerusalem

93053

Novartis Investigative Site, Regensburg

93103

Novartis Investigative Site, Santa Barbara

94000

Novartis Investigative Site, Créteil

94040

Novartis Investigative Site, Mountain View

95123

Novartis Investigative Site, Catania

100044

Novartis Investigative Site, Beijing

100730

Novartis Investigative Site, Beijing

119021

Novartis Investigative Site, Moscow

200080

Novartis Investigative Site, Shanghai

214002

Novartis Investigative Site, Wuxi

300020

Novartis Investigative Site, Tianjin

300070

Novartis Investigative Site, Tianjin

325027

Novartis Investigative Site, Wenzhou

400038

Novartis Investigative Site, Chongqing

410012

Novartis Investigative Site, Saratov

428028

Novartis Investigative Site, Cheboksary

430070

Novartis Investigative Site, Wuhan

453128

Novartis Investigative Site, Sterlitamak

510060

Novartis Investigative Site, Guangzhou

610041

Novartis Investigative Site, Chengdu

4941492

Novartis Investigative Site, Petah Tikva

6093000

Novartis Investigative Site, Ẕerifin

02180

Novartis Investigative Site, Stoneham

07003

Novartis Investigative Site, Bloomfield

53705-3611

Novartis Investigative Site, Madison

A-8036

Novartis Investigative Site, Graz

T2H0C8

Novartis Investigative Site, Calgary

N6A 4V2

Novartis Investigative Site, London

K1Z 8R2

Novartis Investigative Site, Ottawa

M5T 2S8

Novartis Investigative Site, Toronto

G1S 4L8

Novartis Investigative Site, Québec

532 03

Novartis Investigative Site, Pardubice

100 34

Novartis Investigative Site, Prague

F 13008

Novartis Investigative Site, Marseille

04103

Novartis Investigative Site, Leipzig

Unknown

Novartis Investigative Site, Hong Kong

00133

Novartis Investigative Site, Roma

00198

Novartis Investigative Site, Roma

467-8602

Novartis Investigative Site, Nagoya

660 8550

Novartis Investigative Site, Amagasaki

315-0037

Novartis Investigative Site, Ishioka

101-8309

Novartis Investigative Site, Chiyoda-ku

111-0051

Novartis Investigative Site, Taito-ku

543-0027

Novartis Investigative Site, Osaka

00612

Novartis Investigative Site, Arecibo

950 01

Novartis Investigative Site, Nitra

960 01

Novartis Investigative Site, Zvolen

08190

Novartis Investigative Site, Sant Cugat del Vallès

08021

Novartis Investigative Site, Barcelona

SS0 0RY

Novartis Investigative Site, Westcliff-on-Sea

BD9 6RJ

Novartis Investigative Site, Bradford

B18 7QH

Novartis Investigative Site, Birmingham

L7 8XP

Novartis Investigative Site, Liverpool

NW3 2QG

Novartis Investigative Site, London