High Dose Ascorbic Acid (AA) + Nanoparticle Paclitaxel Protein Bound + Cisplatin + Gemcitabine (AA NABPLAGEM) in Patients Who Have Metastatic Pancreatic Cancer

"Four escalating dose levels are planned in order to determine the MTD for Phase II~The dose level for Phase II patients will be determined following completion of the Phase 1b study based on response from 3-6 patients receiving the designated dose level of ascorbic acid."

30 minute IV infusions on days 1 and 8 repeated every 21 days, followed by Cisplatin

60minute IV infusion on days 1 and 8 repeated every 21 days followed by Gemcitabine

30 minute IV infusion on days 1 and 8 repeated every 21 days