Tofacitinib Hypothesis-generating, Pilot Study for Corticosteroid-Dependent Sarcoidosis

PHASE1CompletedINTERVENTIONAL
Enrollment

5

Participants

Timeline

Start Date

May 15, 2019

Primary Completion Date

June 24, 2020

Study Completion Date

June 24, 2021

Conditions
Sarcoidosis, PulmonarySarcoidosis LungSarcoidosis
Interventions
DRUG

Tofacitinib 5mg Oral Tablet [Xeljanz] 16 week trial

Tofacitinib 5mg oral table twice daily for 16 weeks

DIAGNOSTIC_TEST

Spirometry

Spirometry testing at baseline, week 4, week 8, week 12, and week 16

GENETIC

RNA Sequencing

RNA sequencing test at baseline and week 16

DIAGNOSTIC_TEST

Laboratory testing

Laboratory testing at baseline and weeks 2, 4, 8, 12 and 16

DRUG

Corticosteroid

Taper corticosteroids starting at week 4

DRUG

Tofacitinib 5mg [Xeljanz] 1 year open-label extension

After 16 weeks, subjects who meet the primary end-point will be permitted an optional one year open-label extension.

Trial Locations (1)

97239

Oregon Health & Science University, Portland

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Pfizer

INDUSTRY

lead

Oregon Health and Science University

OTHER