Safety, Tolerability, Pharmacokinetics, and Efficacy of Acapatamab in Subjects With mCRPC

PHASE1TerminatedINTERVENTIONAL
Enrollment

212

Participants

Timeline

Start Date

February 5, 2019

Primary Completion Date

June 29, 2023

Study Completion Date

June 29, 2023

Conditions
Metastatic Castration-resistant Prostate CancerProstate Cancer
Interventions
DRUG

acapatamab

Investigational immunotherapy for the treatment of metastatic castration-resistant prostate cancer

DRUG

Pembrolizumab

Combined with acapatamab for investigational treatment of mCRPC

DRUG

Etanercept

Prophylaxis for acapatamab-related cytokine release syndrome.

DRUG

Cytochrome P450 (CYP) Cocktail

Evaluate the effect of co-administration of multiple dosing of acapatamab on plasma

Trial Locations (30)

1020

Krankenhaus der Barmherzigen Brueder Wien, Vienna

1090

Universitaetsklinikum Allgemeines Krankenhaus Wien, Vienna

1200

Universite Catholique de Louvain Cliniques Universitaires Saint Luc, Brussels

2031

Scientia Clinical Research Ltd, Randwick

2050

Chris OBrien Lifehouse, Camperdown

3050

Peter MacCallum Cancer Centre, Parkville

4020

Ordensklinikum Linz Elisabethinen, Linz

5020

Landeskrankenhaus Salzburg, Salzburg

9000

Universitair Ziekenhuis Gent, Ghent

10065

Memorial Sloan Kettering Cancer Center, New York

Weill Cornell Medical College, New York

30322

Emory University, Atlanta

33305

Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation, Taoyuan District

46202

Indiana University, Indianapolis

52242

University of Iowa Hospitals and Clinics, Iowa City

63110

Washington University, St Louis

70112

Tulane Medical Center, New Orleans

75390

University of Texas Southwestern Medical Center, Dallas

89169

Comprehensive Cancer Centers of Nevada, Las Vegas

90095

University of California Los Angeles, Los Angeles

90813

City of Hope at Long Beach Elm, Long Beach

91010

City of Hope National Medical Center, Duarte

94805

Institut Gustave Roussy, Villejuif

95008

El Camino Hospital, Campbell

119074

National University Hospital, Singapore

169610

National Cancer Centre Singapore, Singapore

V5Z 4E6

BC Cancer Vancouver, Vancouver

277-8577

National Cancer Center Hospital East, Kashiwa-shi

232-0024

Yokohama City University Medical Center, Yokohama

3015 GD

Erasmus Medisch Centrum, Rotterdam

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY