MG4101 Plus Rituximab Including Lymphodepletion in Patient With r/r NHL B-cell Origin

PHASE1/PHASE2UnknownINTERVENTIONAL
Enrollment

9

Participants

Timeline

Start Date

November 28, 2018

Primary Completion Date

April 20, 2020

Study Completion Date

October 30, 2020

Conditions
Relapsed Non Hodgkin LymphomaRefractory Non-Hodgkin Lymphoma
Interventions
DRUG

Rituximab

weekly administration of Rituximab 375mg/m2 during cycle 1 and 2, monthly administration from cycle 3(up to cycle 6)

DRUG

Fludarabine

administration of fludarabine 20mg/m2 for 3 consecutive days starting at 3 days before the 1st, 3rd, and 5th cycle of the first rituximab infusion for that cycle

DRUG

Cyclophosphamide

administration of fludarabine 250mg/m2 for 3 consecutive days starting at 3 days before the 1st, 3rd, and 5th cycle of the first rituximab infusion for that cycle

BIOLOGICAL

MG4101(allogeneic Natural Killer cell)

administration every fortnight for each cycle, beginning with the 1st dose of rituximab for that cycle.

DRUG

Interleukin-2

1 x 10\^6 IU/m2, together with MG4101

Trial Locations (3)

Unknown

Asan Medical Center, Seoul

Samsung Medical Center, Seoul

Seoul National Univ. Hospital, Seoul

Sponsors
All Listed Sponsors
lead

GC Cell Corporation

INDUSTRY