Study of Durvalumab+Olaparib or Durvalumab After Treatment With Durvalumab and Chemotherapy in Patients With Lung Cancer (ORION)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

401

Participants

Timeline

Start Date

December 21, 2018

Primary Completion Date

January 11, 2021

Study Completion Date

September 27, 2026

Conditions
Non-small Cell Lung Cancer NSCLC
Interventions
DRUG

Durvalumab

Initial therapy phase: IV infusion q3w for 4 cycles. Maintenance phase: IV infusion q4w.

DRUG

Placebo for Olaparib

Matching tablet

DRUG

Olaparib

150-mg tablets (2 × 150-mg tablets for 300-mg dose) 100-mg tablet available if dose reductions are required

DRUG

Nab-paclitaxel+carboplatin

Standard of Care chemotherapy (squamous and non-squamous patients)

DRUG

Gemcitabine+carboplatin

Standard of Care chemotherapy (squamous patients only)

DRUG

Pemetrexed+carboplatin

Standard of Care chemotherapy (non-squamous patients only)

DRUG

Gemcitabine+cisplatin

Standard of Care chemotherapy (squamous patients only)

DRUG

Pemetrexed+cisplatin

Standard of Care chemotherapy (non-squamous patients only)

Trial Locations (69)

1088

Research Site, Budapest

1122

Research Site, Budapest

1261

Research Site, Blaricum

2045

Research Site, Törökbálint

3000

Research Site, Leuven

3844

Research Site, Harderwijk

4032

Research Site, Debrecen

6772

Research Site, Deszk

8582

Research Site, Farkasgyepü

8800

Research Site, Roeselare

9300

Research Site, Aalst

10408

Research Site, Goyang-si

16247

Research Site, Suweonsi Paldalgu

18015

Research Site, Bethlehem

25006

Research Site, Kirovohrad

31200

Research Site, Chihuahua City

33401

Research Site, West Palm Beach

33705

Research Site, St. Petersburg

34135

Research Site, Bonita Springs

37203

Research Site, Nashville

37404

Research Site, Chattanooga

49102

Research Site, Dnipro

61024

Research Site, Kharkiv Region

64132

Research Site, Kansas City

65055

Research Site, Odesa

69059

Research Site, Zaporizhzhia

77090

Research Site, Houston

78250

Research Site, San Luis Potosí City

80230

Research Site, Culiacán

88000

Research Site, Uzhhorod

115478

Research Site, Moscow

125284

Research Site, P. Herzen Moscow Oncology Rese

150054

Research Site, Yaroslavl

163045

Research Site, Arkhangelsk

197022

Research Site, Saint Petersburg

305524

Research Site, Kursk

354000

Research Site, Sochi

360000

Research Site, Nal'chik

361008

Research Site, Jamnagar

380009

Research Site, Ahmedabad

380053

Research Site, Ahmedabad

411001

Research Site, Pune

422004

Research Site, Nashik

422005

Research Site, Nashik

422009

Research Site, Nashik

454092

Research Site, Chelyabinsk

570021

Research Site, Mysuru

682026

Research Site, Kochi

695011

Research Site, Thiruvananthapuram

32308-5304

Research Site, Tallahassee

104-0045

Research Site, Chūōku

920-8641

Research Site, Kanazawa

830-0011

Research Site, Kurume-shi,

791-0280

Research Site, Matsuyama

460-0001

Research Site, Nagoya

980-0873

Research Site, Sendai

411-8777

Research Site, Sunto-gun

755-0241

Research Site, Ube-shi

5022 GC

Research Site, Tilburg

15-540

Research Site, Bialystok

90-302

Research Site, Lodz

60-693

Research Site, Poznan

82-550

Research Site, Prabuty

07061

Research Site, Dongjakgu

03722

Research Site, Seodaemun-gu

05505

Research Site, Seoul

06351

Research Site, Seoul

DD1 9SY

Research Site, Dundee

HU6 7RX

Research Site, Hull

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY