IL-1 Signal Inhibition in Alcoholic Hepatitis

PHASE2CompletedINTERVENTIONAL
Enrollment

55

Participants

Timeline

Start Date

February 12, 2019

Primary Completion Date

March 31, 2023

Study Completion Date

March 31, 2023

Conditions
Alcoholic Hepatitis
Interventions
DRUG

Canakinumab 150mg/ml solution for injection

Canakinumab 150mg/ml solution for injection

DRUG

Placebo

100ml 5% Dextrose

Trial Locations (16)

Unknown

University Hospitals Bristol NHS Foundation Trust, Bristol

Queen Elizabeth University Hospital, Glasgow

Leeds Teaching Hospitals NHS Trust, Leeds

Aintree University Hospital, Liverpool

Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool

Chelsea and Westminster Hospital NHS Foundation Trust, London

King's College Hospital NHS Foundation Trust, London

Royal Free London NHS Foundation Trust, London

St George's University Hospitals NHS Foundation Trust, London

The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne

Nottingham University Hospitals NHS Trust, Nottingham

Plymouth Hospitals NHS Trust, Plymouth

University Hospital Southampton NHS Foundation Trust, Southampton

G4 0SF

Glasgow Royal Infirmary, Greater Glasgow & Clyde, Glasgow

W2 1NY

Imperial College Healthcare NHS Foundation Trust, London

OX3 9DU

John Radcliffe Hospital, Oxford University NHS Foundation Trust, Oxford

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Novartis Pharmaceuticals

INDUSTRY

lead

Imperial College London

OTHER