Evaluate the Safety, Tolerability, Biodistribution and Anti Tumour Activity of 177LU-OPS201 With Companion Imaging 68Ga-OPS202 PET/CT in Previously Treated Subjects With Locally Advanced or Metastatic Cancers Expressing Somatostatin Receptor 2 (SSTR2)

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

9

Participants

Timeline

Start Date

May 14, 2019

Primary Completion Date

October 10, 2019

Study Completion Date

October 10, 2019

Conditions
Small Cell Lung Cancer and Breast Cancer
Interventions
DRUG

Satoreotide tetraxetan

Radioactivity delivered in 2 administrations (cycles): one loading dose followed by a lower maintenance dose, 6 weeks apart until progression or unacceptable toxicity (up to 4 additional cycles could be administered depending on efficacy and tolerability).

DRUG

Satoreotide trizoxetan

Imaging companion: 1 administration at screening and one administration at End of core Trial cycle.

Trial Locations (8)

3000

University Hospital (UZ) Leuven, Leuven

6020

Medical University of Innsbruck, Innsbruck

13385

CHU de Marseille - Hôpital la Timone, Marseille

33604

CHU de Bordeaux - Hôpital Haut Lévêque, Pessac

45122

Universitaetsklinikum Essen, Essen

77030

MD Anderson Cancer Center, Houston

CH-4031

University Hospital Basel, Basel

SM2 5PT

Royal Marsden Hospital - Surrey, Sutton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Ipsen

INDUSTRY