A Trial of Fedratinib in Subjects With DIPSS, Intermediate or High-Risk Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib

PHASE3TerminatedINTERVENTIONAL
Enrollment

38

Participants

Timeline

Start Date

March 27, 2019

Primary Completion Date

November 26, 2021

Study Completion Date

November 8, 2023

Conditions
Primary MyelofibrosisPost-Polycythemia Vera MyelofibrosisMyelofibrosisPost-essential Thrombocythemia Myelofibrosis
Interventions
DRUG

FEDRATINIB

A potent and selective inhibitor of JAK2 kinase activity

Trial Locations (35)

10029

Local Institution - 115, New York

10032

Local Institution - 124, New York

11212

Local Institution - 130, Brooklyn

13210

SUNY Upstate Medical University, Syracuse

15224

Local Institution - 106, Pittsburgh

20817

Local Institution - 118, Bethesda

21044

Local Institution - 127, Columbia

27514

Local Institution - 105, Chapel Hill

27705

Local Institution - 114, Durham

30912

Local Institution - 113, Augusta

33176

Local Institution - 126, Miami

45219

Local Institution - 111, Cincinnati

48109

Local Institution - 103, Ann Arbor

57105

Local Institution - 108, Sioux Falls

60068

Local Institution - 121, Park Ridge

60612

Local Institution - 112, Chicago

60637

Local Institution - 109, Chicago

63110

Local Institution - 101, St Louis

76104

Local Institution - 132, Fort Worth

77303

Local Institution - 110, Houston

78229

Local Institution - 120, San Antonio

80045

Local Institution - 117, Aurora

98109

Local Institution - 116, Seattle

66160-7314

Local Institution - 100, Kansas City

21229-5299

Local Institution - 123, Baltimore

07112-2027

Local Institution - 128, Newark

75390-8852

Local Institution - 119, Dallas

53792-2454

Local Institution - 129, Madison

V6Z 2A5

Local Institution - 203, Vancouver

N6C 6B5

Local Institution - 207, London

K1H 8L6

Local Institution - 205, Ottawa

M5G 2M9

Local Institution - 200, Toronto

H1T 2M4

Local Institution - 201, Montreal

H3T 1E2

Local Institution - 202, Montreal

J1K 2R1

Local Institution - 204, Sherbrooke

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Impact Biomedicines, Inc., a wholly owned subsidiary of Celgene Corporation

INDUSTRY

lead

Celgene

INDUSTRY

NCT03755518 - A Trial of Fedratinib in Subjects With DIPSS, Intermediate or High-Risk Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib | Biotech Hunter | Biotech Hunter