Sintilimab or Placebo With Chemotherapy in Esophageal Squamous Cell Carcinoma ( ORIENT-15 )

PHASE3CompletedINTERVENTIONAL
Enrollment

746

Participants

Timeline

Start Date

December 24, 2018

Primary Completion Date

September 9, 2021

Study Completion Date

July 29, 2023

Conditions
Esophageal Squamous Cell Carcinoma
Interventions
BIOLOGICAL

Sintilimab

For weight \<60kg, 3mg/kg IV Q3W day 1, and for weight≥60kg, 200mg IV Q3W day 1

DRUG

Cisplatin

75mg/m\^2 IV Q3W day 1

DRUG

Paclitaxel

87.5 mg/m\^2 IV Q3W day 1, day 8 for first cycle and 175mg/m\^2 IV Q3W day 1 after first cycle

DRUG

Fluorouracil

800 mg/m\^2 IV continuous infusion over 24 hours daily on Days 1-5 Q3W

DRUG

Placebo

For weight \<60kg, 3mg/kg IV Q3W day 1, and for weight≥60kg, 200mg IV Q3W day 1

Trial Locations (48)

1000

Institut Jules Bordet, Brussels

1122

Országos Onkológiai Intézet, Budapest

1200

Cliniques Universitaires Saint-Luc Av., Brussels

2640

Border Medical Oncology, East Albury

3000

Universitair Ziekenhuis Leuven, Leuven

3079

Austin Hospital, Heidelberg

4400

Jósa András Oktatókórház, Nyíregyháza

4800

Centre Hospitalier Regional de Verviers, Verviers

5011

The Queen Elizabeth Hospital, Woodville South

6008

St John of God Subiaco Hospital, Subiaco

6009

Sir Charles Gairdner Hospital, Nedlands

9000

University Hospital Gent, Ghent

13005

CHU Hôpital de la Timone, Marseille

14000

Centre François Baclesse, Caen

15706

Complexo Hospitalario Universitario de Santiago, Santiago de Compostela

21000

Faculte de Medecine, Dijon

21079

Universite de Bourgogne - Faculte de Medecine - INSERM U866, Dijon

25000

Hôpital Jean Minjoz, Bettancourt-la-Ferrée

25198

Hospital Universitari Arnau de Vilanova de Lleida, Lleida

28046

Hospital Universitario La Paz, Madrid

28942

Hospital Universitario de Fuenlabrada, Fuenlabrada

31008

Clínica Universidad de Navarra, Pamplona

31904

IACT Health - John B. Amos Cancer center, Columbus

33000

Institut Bergonié, Bordeaux

39008

University Hospital Marqués de Valdecilla, Santander

41003

Hospital Universitario Virgen Macarena, Seville

46016

Consorci Hospital General Universitari de València, Valencia

50009

Hospital Universitario Miguel Servet, Zaragoza

54500

Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy

59020

Oscar Lambret Centre, Lille

63000

CHU Estaing, Clermont-Ferrand

63100

CHU Estaing, Clermont-Ferrand

73104

Stephenson Cancer Center, Oklahoma City

75015

Hôpital Européen Georges Pompidou, Paris

76000

Hôpital Charles-Nicolle de Rouen, Rouen

78705

Texas Oncology, P.A., Austin

80218

Rocky Mountain Cancer Centers, LLP, Denver

86021

CHU de Poitiers, Poitiers

92835

St. Joseph Heritage Healthcare - Virginia K. Crosson Cancer Center, Anaheim

92868

UC Irvine, Orange

98684

Northwest Cancer Specialists, P.C., Vancouver

280402

Hospital Universitario Fundacion Jimenez Diaz, Madrid

Unknown

Beijing Cancer Hospital, Beijing

Hospital Universitari de Girona Doctor Josep Trueta, Girona

Hospital Universitario Ramón y Cajal, Madrid

08001

Hospital del Mar, Barcelona

08035

Hospital Universitario Vall d'Hebron, Barcelona

08208

Parc Taulí Sabadell Hospital Universitari, Sabadell

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Fortrea

INDUSTRY

lead

Innovent Biologics (Suzhou) Co. Ltd.

INDUSTRY