Neoadjuvant Her2-targeted Therapy and Immunotherapy With Pembrolizumab [IIT2018-04-MCARTHUR-NEOHP]

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

138

Participants

Timeline

Start Date

January 25, 2019

Primary Completion Date

November 8, 2024

Study Completion Date

December 31, 2029

Conditions
HER2-positive Breast CancerBreast Cancer
Interventions
DRUG

Paclitaxel

All subjects will receive Paclitaxel weekly for 12 weeks

DRUG

Trastuzumab

All subjects will receive Trastuzumab every 3 weeks

DRUG

Pertuzumab

Arm A and Arm B subjects will receive Pertuzumab every 3 weeks

DRUG

Pembrolizumab

Arm B and Arm C subjects will receive Pembrolizumab every 3 weeks

Trial Locations (5)

87109

New Mexico Cancer Center, Albuquerque

90048

Cedars Sinai Medical Center, Los Angeles

97213

Providence Cancer Institute, Portland

02114

Massachusetts General Hospital, Boston

75006-7541

UT Southwestern Medical Center, Dallas

Sponsors
All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

collaborator

Breast Cancer Research Foundation

OTHER

lead

University of Texas Southwestern Medical Center

OTHER