WIRE - Novel Treatments in Renal Cell Cancer

Olaparib 300mg twice daily, oral medication administered for at least 2 weeks and up until the morning of nephrectomy. Arms 2, 3 and 5

Cediranib 20mg once daily, oral medication administered for at least 2 weeks until 36 hours prior to nephrectomy. Arms 1 and 3

Durvalumab 1500mg intravenous infusion administered once, no greater than 4 weeks prior to nephrectomy