A Study Comparing ATB200/AT2221 With Alglucosidase Alfa/Placebo in Adult Subjects With Late-onset Pompe Disease

PHASE3CompletedINTERVENTIONAL
Enrollment

125

Participants

Timeline

Start Date

December 4, 2018

Primary Completion Date

December 15, 2020

Study Completion Date

January 15, 2021

Conditions
Pompe Disease (Late-onset)
Interventions
BIOLOGICAL

Cipaglucosidase Alfa

Participants received an intravenous (IV) infusion dose over a 4-hour duration every 2 weeks (Q2W).

DRUG

Miglustat

Participants received weight-based doses 1 hour prior to cipaglucosidase alfa infusion Q2W.

BIOLOGICAL

Alglucosidase Alfa

Participants received an IV infusion dose over a 4-hour duration Q2W.

DRUG

Placebo

Miglustat matching placebo was administered orally 1 hour prior to alglucosidase alfa infusion Q2W.

Trial Locations (73)

100

National Taiwan University Hospital, Taipei

1000

University Medical Centre Ljubljana, Ljubljana

1083

Semmelweis University, Institute of Genomic Medicine and Rare Disease, Budapest

2100

Rigshospitalet Copenhagen Neuromuscular Center, Copenhagen

2145

Westmead Hospital, Westmead

3000

UZ Leuven, Leuven

3168

Monash Medical Centre, Melbourne

4029

Royal Brisbane & Women's Hospital, Herston

5000

Royal Adelaide Hospital, Adelaide

6725

University of Szeged, Szeged

7623

University of Pécs, Pécs

8200

Aarhus Universitets Hospital, Aarhus N

10017

NYU School of Medicine, New York

11030

The Feinstein Institute for Medical Research, Manhasset

11528

Eginition Hospital, Athens

13385

Hôpital de la Timone, Marseille

15213

University of Pittsburgh, Pittsburgh

17033

Penn State Health Milton S. Hershey Medical Center, Hershey

19104

University of Pennsylvania, Philadelphia

22030

Lysosomal and Rare Disorders Research, Fairfax

27710

Duke University Medical Center, Durham

30322

Emory Clinic, Atlanta

32610

UF Helath: University of Florida Clinical Research Center, Gainesville

33612

University of South Florida Research Center, Tampa

41345

Sahlgrenska University Hospital, Gothenburg

43210

The Ohio State University Wexner Medical Center, Columbus

45219

University of Cincinnati Neurology, Cincinnati

45229

Cincinnati Children's Hospital Medical Center, Cincinnati

46202

Indiana University Health Neuroscience Center, Indianapolis

48149

Universitätsklinikum Münster, Münster

50612

Pusan National University, Yangsan

53105

Universitätsklinikum Bonn, Bonn

55455

University of Minnesota Clinical Research Unit, Minneapolis

59037

Hôpital Salengro, Lille

59101

Billings Clinic, Billings

63110

Washington University School of Medicine, St Louis

66205

University of Kansas Medical Center, Kansas City

69677

Hôpital Neurologique Pierre Wertheimer, Bron

72205

University of Arkansas for Medical Sciences, Little Rock

78000

University Clinical Centre of the Republic of Srpska, Banja Luka

78229

University of Texas Health Science Center San Antonio, San Antonio

80131

UOC Genetica Medica, Napoli

80336

Friedrich-Baur Institut, Munich

84108

University of Utah, Center for Clinical and Translational Sciences, Salt Lake City

85028

Neuromuscular Research Center, Phoenix

92380

Hôpital Raymond Poincaré, Garches

92868

University of California, Irvine, Irvine

97239

Oregon Health & Science University, Portland

98125

UOC di Neurologia e Malattie Neuromuscolari, Messina

07601

Hackensack University Medical Center, Hackensack

B1629ODT

Hospital Universitario Austral, Buenos Aires

Unknown

Medizinische Universität Innsbruck, Innsbruck

UMHAT Alexandrovska, Sofia

Kagoshima University Hospital, Kagoshima

Izumi City General Hospital, Osaka

National Center of Neurology and Psychiatry, Tokyo

University of Auckland, Auckland

Queen Elizabeth Hospital Birmingham, Birmingham

Cambridge University Hospitals, Cambridge

T2N 4Z6

Heritage Medical Research Clinic, University of Calgary, Calgary

L8N 3Z5

McMaster University Medical Centre, Hamilton

06001

Hôpital Pasteur, Nice

06120

Universitätsklinikum Halle (Saale), Halle

060 8648

Hokkaido University Hospital, Sapporo

814-0180

Fukuoka University Hospital, Fukuoka

105-8471

The Jikei University Hospital, Tokyo

3015GD

Erasmus MC, Rotterdam

31-066

Szpital Uniwersytecki w Krakowie, Małogoskie

35-326

Centrum Medyczne, Rzeszów

03080

Seoul National University Hospital, Seoul

08026

Hospital de la Santa Creu I Sant Pau, Barcelona

NW3 2QG

Royal Free Hospital NHS, London

M6 8HD

Salford Royal NHS Foundation Trust, Salford

Sponsors
All Listed Sponsors
lead

Amicus Therapeutics

INDUSTRY

NCT03729362 - A Study Comparing ATB200/AT2221 With Alglucosidase Alfa/Placebo in Adult Subjects With Late-onset Pompe Disease | Biotech Hunter | Biotech Hunter