Regorafenib Combined With Irinotecan as Second-line in Patients With Metastatic Gastro-oesophageal Adenocarcinomas

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

89

Participants

Timeline

Start Date

February 7, 2019

Primary Completion Date

May 19, 2022

Study Completion Date

May 19, 2022

Conditions
Adenocarcinoma of the StomachAdenocarcinoma of the Gastroesophageal Junction
Interventions
COMBINATION_PRODUCT

Regorafenib and Irinotecan

Irinotecan (180 mg/m² on D1 and D15 of a 4-week cycle) combined with regorafenib (160 mg daily on D2-8 and D16-22 of a 4-week cycle) administered until progression of disease or unacceptable toxicity

DRUG

Irinotecan

Irinotecan (180 mg/m² on D1 and D15 of a 4-week cycle) administered until progression of disease or unacceptable toxicity

Trial Locations (27)

21079

Centre Georges François Leclerc, Dijon

34298

Institut du Cancer Montpellier, Montpellier

51100

Institut Jean Godinot, Reims

54500

CHU Nancy - Hôpital Brabois, Vandœuvre-lès-Nancy

75015

Hopital Europeen Georges Pompidou, Paris

86000

CHU de Poitiers, Poitiers

Unknown

Institut de Cancérologie de l'Ouest-Paul Papin, Angers

Hôpital Morvan, Brest

Clinique de Flandre, Coudekerque-Branche

Hôpital Franco-Britannique, Levallois-Perret

Hopital Claude Huriez - CHU Lille, Lille

CHU Dupuytren, Limoges

Centre Léon Bérard, Lyon

Hopital de la Timone, Marseille

Institut Paoli Calmette, Marseille

Centre de Cancérologie du Grand Montpellier, Montpellier

GH Diaconesses Croix Saint-Simon, Paris

CH Saint Jean, Perpignan

CH Annecy Genevois, Pringy

Hopital Robert Debre, Reims

Hopital Charles Nicolle, Rouen

CHP Saint Grégoire, Saint-Grégoire

Institut de Cancérologie de l'Ouest-René Gauducheau, Saint-Herblain

CH Saint Malo, St-Malo

Centre Paul Strass, Strasbourg

CHRU Tours, Tours

06189

Centre Antoine Lacassagne, Nice

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bayer

INDUSTRY

lead

UNICANCER

OTHER