Study of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory Neuroblastoma or Relapsed/Refractory Osteosarcoma

PHASE1RecruitingINTERVENTIONAL
Enrollment

18

Participants

Timeline

Start Date

February 19, 2019

Primary Completion Date

May 19, 2030

Study Completion Date

June 19, 2044

Conditions
NeuroblastomaOsteosarcoma
Interventions
BIOLOGICAL

iC9.GD2.CAR.IL-15 T-cells

Three dose levels are being evaluated: 0.5 x 10\^6, 1.0 x 10\^6, 1.5 x 10\^6

DRUG

Cyclophosphamide

500 mg/m\^2 IV dose on days 1-2 for lymphodepletion prior to cell infusion

DRUG

Fludarabine

30 mg/m\^2 IV dose on days 1-4 for lymphodepletion prior to cell infusion

Trial Locations (2)

30322

WITHDRAWN

Emory - Winship Cancer Institute, Atlanta

27599-7295

RECRUITING

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill

Sponsors

Collaborators (1)

All Listed Sponsors
lead

UNC Lineberger Comprehensive Cancer Center

OTHER

collaborator

United States Department of Defense

FED

collaborator

Bellicum Pharmaceuticals

INDUSTRY

collaborator

National Cancer Institute (NCI)

NIH

NCT03721068 - Study of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory Neuroblastoma or Relapsed/Refractory Osteosarcoma | Biotech Hunter | Biotech Hunter