Chemoimmunotherapy and Allogeneic Stem Cell Transplant for NK T-cell Leukemia/Lymphoma

EARLY_PHASE1RecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

March 1, 2019

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2028

Conditions
NK-Cell LymphomaNK-Cell LeukemiaPeripheral T Cell Lymphoma
Interventions
DRUG

Methotrexate

Patients will receive methotrexate as part of chemoimmunotherapy regemin followed by allogeneic stem cell transplant.

DRUG

pralatraxate,

Patients will receive pralaxtraxate as part of chemoimmunotherapy regimen followed by allogeneic stem cell transplant.

DRUG

Ifosfamide

Patients will receive Ifsofamide as part of chemoimmunotherapy regimen followed by allogeneic stem cell transplant.

DRUG

Dexamethasone

Patients will receive dexamethasone as part of chemoimmunotherapy regimen followed by allogeneic stem cell transplant.

DRUG

Etoposide

Patients will receive etoposide as part of chemoimmunotherapy regimen followed by allogeneic stem cell transplant.

DRUG

calaspargase pegol

Patients will receive pegaspargase as part of chemoimmunotherapy regimen followed by allogeneic stem cell transplant.

DRUG

cyclophosphamide

Patients will receive cyclophosphamide as part of chemoimmunotherapy regimen followed by allogeneic stem cell transplant.

DRUG

Doxorubicin

Patients will receive doxorubicin as part of chemoimmunotherapy regimen followed by allogeneic stem cell transplant.

DRUG

Prednisone

Patients will receive prednisone as part of chemoimmunotherapy regimen followed by allogeneic stem cell transplant.

DRUG

Brentuximab Vedotin

Patients will receive brentuximab vedotin as part of chemoimmunotherapy regimen followed by allogeneic stem cell transplant.

Trial Locations (6)

10595

RECRUITING

New York Medical College, Valhalla

35223

RECRUITING

University of Alabama, Birmingham

43205

RECRUITING

Nationwide Children's Hospital, Columbus

49503

RECRUITING

Helen De Vos, Grand Rapids

92968

RECRUITING

Children's Hospital Orange County, Orange

94143

RECRUITING

University of California San Francisco, San Francisco

Sponsors
All Listed Sponsors
collaborator

University of Alabama at Birmingham

OTHER

lead

New York Medical College

OTHER