100
Participants
Start Date
January 14, 2020
Primary Completion Date
January 1, 2026
Study Completion Date
June 1, 2026
Intraoperative Intraosseous Vancomycin
After debridement and irrigation the interventional group will receive intraosseous vancomycin 500mg in 150ml of normal saline. This solution will be prepared by the hospital pharmacy and administered via an EZ-IO intraosseous cannula. 75ccs of the vancomycin solution will be injected as a bolus. Subsequent to this the remaining 75ccs will be placed in the distal femur just proximal to the femoral component evenly split between the medial and lateral femoral condyles in knees.
New York University - Langone, New York
Atrium Mercy Hospital, Charlotte
OrthoCarolina Research Institute/OrthoCarolina, Charlotte
Novant Health Charlotte Orthopedic Hospital, Charlotte
University of Florida, Gainesville
Cleveland Clinic Florida, Weston
Rush University, Chicago
University of Nebraska, Omaha
University of Utah, Salt Lake City
University of California, San Francisco, San Francisco
American Association of Hip and Knee Surgeons
OTHER
OrthoCarolina Research Institute, Inc.
OTHER