Pilot Immunotherapy Study With Letetresgene Autoleucel (Lete-cel, GSK3377794)T-cells in New York Esophageal Squamous Cell Carcinoma-1 (NY-ESO-1)/ LAGE-1a-positive Advanced Non-small Cell Lung Cancer (NSCLC) Either Alone or in Combination With Pembrolizumab

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

34

Participants

Timeline

Start Date

December 31, 2018

Primary Completion Date

June 27, 2022

Study Completion Date

November 4, 2022

Conditions
Neoplasms
Interventions
DRUG

Lete-cel

lete-cel will be administered to eligible participants.

DRUG

Pembrolizumab

Pembrolizumab will be administered to eligible participants.

Trial Locations (31)

10065

GSK Investigational Site, New York

15232

GSK Investigational Site, Pittsburgh

19111

GSK Investigational Site, Philadelphia

21201

GSK Investigational Site, Baltimore

27710

GSK Investigational Site, Durham

28040

GSK Investigational Site, Madrid

28050

GSK Investigational Site, Madrid

30322

GSK Investigational Site, Atlanta

33021

GSK Investigational Site, Hollywood

37203

GSK Investigational Site, Nashville

40536

GSK Investigational Site, Lexington

43210

GSK Investigational Site, Columbus

52242

GSK Investigational Site, Iowa City

60637

GSK Investigational Site, Chicago

63110

GSK Investigational Site, St Louis

77030

GSK Investigational Site, Houston

80218

GSK Investigational Site, Denver

91010

GSK Investigational Site, Duarte

94305

GSK Investigational Site, Stanford

95817

GSK Investigational Site, Sacramento

92093-0987

GSK Investigational Site, La Jolla

84112-5550

GSK Investigational Site, Salt Lake City

M5G 1X6

GSK Investigational Site, Toronto

H2X 0A9

GSK Investigational Site, Montreal

1066 CX

GSK Investigational Site, Amsterdam

9713 GZ

GSK Investigational Site, Groningen

3015 GD

GSK Investigational Site, Rotterdam

3584 CX

GSK Investigational Site, Utrecht

08035

GSK Investigational Site, Barcelona

WC1E 6AG

GSK Investigational Site, London

M20 4BX

GSK Investigational Site, Manchester

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

GlaxoSmithKline

INDUSTRY

NCT03709706 - Pilot Immunotherapy Study With Letetresgene Autoleucel (Lete-cel, GSK3377794)T-cells in New York Esophageal Squamous Cell Carcinoma-1 (NY-ESO-1)/ LAGE-1a-positive Advanced Non-small Cell Lung Cancer (NSCLC) Either Alone or in Combination With Pembrolizumab | Biotech Hunter | Biotech Hunter