Long Term Follow up of Children Enrolled in the REDvent Study

Ventilation inhomogeneity will be measured using the Lung Clearance Index (LCI), derived from multiple breath Nitrogen washout during tidal breathing, measured by a mouthpiece or mask covering nose and mouth.

Diaphragm thickness and contractile activity measured during tidal breathing.

Measure of thoraco-abdominal asynchrony during tidal breathing

Measurement of Forced Expiratory Volume (FEV1), Forced Vital Capacity and other lung volumes using standard pulmonary function techniques

Measurement using body box plethysmography of functional residual capacity and other lung volumes using standard pulmonary function techniques

Measurement of maximal inspiratory and expiratory pressures during airway occlusion

Measurement of cardio-respiratory function and capabilities during treadmill walking for 6 minutes.

Detailed in person neuro-cognitive testing using standardized inventories using either the Battelle Developmental Inventory, second edition (Battelle-2) (age birth to 5 years 11 months) and the Wechsler Intelligence Scale for Children, fifth edition (WISC-5, for age 6 years to 19 years).

In person and written assessments of children and parents using the Behavioral Assessment System for Children, third edition (BASC-3) for children ≥ 2 years and the UCLA PTSD Reaction Index (UCLA RI) for children ≥ 8 years.

Standardized instruments to assess (in person, over the phone, or via mail) health related quality of life in children. Parent and child questionnaires.

Survey of overall functional status, administrated by asking a series of questions to patient and families.

Survey of respiratory health, administrated by asking a series of questions to patient and families.