ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

375

Participants

Timeline

Start Date

May 14, 2019

Primary Completion Date

December 31, 2028

Study Completion Date

June 30, 2032

Conditions
Refractory CancerRecurrent CancerSolid Tumor, AdultCancer
Interventions
BIOLOGICAL

IMA203 Product

The cell dose will be based on viable CD3+CD8+ HLA- Dextramer+ cells per body surface area (BSA) as defined by the Mosteller formula

BIOLOGICAL

IMA203 product- flat dose

The cell dose will be based on viable CD3+CD8+ HLA- Dextramer+ cells

BIOLOGICAL

IMA203CD8 Product

The cell dose will be based on viable CD3+CD8+ HLA- Dextramer+ cells per body surface area (BSA) as defined by the Mosteller formula

DRUG

Nivolumab

Nivolumab will be given post IMA203/IMA203CD8 infusion, after hematologic recovery is achieved. Clinical supply provided by Bristol Myers Squibb.

DEVICE

IMADetect®

IMADetect® is developed as a companion diagnostic to aid in selecting patients with relapsed and/or refractory solid cancers who might be eligible for enrollment in Immatics clinical trials.

Trial Locations (15)

12203

RECRUITING

Charité Benjamin Franklin - Klinik für Hämatologie und Onkologie, Berlin

15232

RECRUITING

University of Pittsburgh Medical Center, Pittsburgh

19104

RECRUITING

University of Pennsylvania, Perelamn Center for Advanced Medicine, Philadelphia

19111

RECRUITING

Fox Chase Cancer Center, Philadelphia

20246

RECRUITING

Universitätsklinikum Hamburg-Eppendorf, Hamburg

33136

RECRUITING

University of Miami Hospital and Clinics, Miami

43026

RECRUITING

Ohio State University Wexner Medical Center Gynecologic Oncology at Mill Run, Columbus

53127

RECRUITING

Universitätsklinikum Bonn - Medizinische Klinik III, Bonn

55131

RECRUITING

Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz

69120

RECRUITING

Universitätsklinikum Heidelberg, Nationales Centrum für Tumorerkrankungen (NCT), Heidelberg

77030

RECRUITING

University of Texas MD Anderson Cancer Center, Houston

81675

RECRUITING

Klinikum rechts der Isar der Technischen Universität München, Munich

97080

RECRUITING

Universitätsklinikum Würzburg, Würzburg

02114

RECRUITING

Massachusetts General Hospital, Boston

01307

RECRUITING

Universitätsklinikum C.-G.-Carus Dresden, Dresden

All Listed Sponsors
lead

Immatics US, Inc.

INDUSTRY