Intratumoral Cavrotolimod Combined With Pembrolizumab or Cemiplimab in Patients With Merkel Cell Carcinoma, Cutaneous Squamous Cell Carcinoma, or Other Advanced Solid Tumors

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

57

Participants

Timeline

Start Date

December 13, 2018

Primary Completion Date

March 30, 2022

Study Completion Date

March 30, 2022

Conditions
Advanced or Metastatic Merkel Cell CarcinomaAdvanced or Metastatic Cutaneous Squamous Cell CarcinomaAdvanced or Metastatic MelanomaAdvanced or Metastatic Head and Neck Squamous Cell CarcinomaAdvanced or Metastatic Solid Tumors
Interventions
DRUG

Cavrotolimod

Intratumorally dosed cavrotolimod.

BIOLOGICAL

Pembrolizumab

Pembrolizumab dosing as per the US prescribing information.

BIOLOGICAL

Cemiplimab

Cemiplimab dosing as per the US prescribing information.

DRUG

Cavrotolimod

Subcutaneously dosed cavrotolimod

Trial Locations (26)

10016

Perlmutter Cancer Center, New York

10065

Memorial Sloan Kettering Cancer Center, New York

15232

University of Pittsburgh Medical Center / Hillman Cancer Center, Pittsburgh

26506

West Virginia Cancer Institute, Morgantown

27710

Duke Cancer Institute, Durham

33136

Sylvester Comprehensive Cancer Center, Miami

40241

Norton Cancer Center, Louisville

43210

Ohio State University Comprehensive Cancer Center, Columbus

45267

University of Cincinnati, Cincinnati

52242

Holden Comprehensive Cancer Center, Iowa City

60611

Northwestern University Feinberg School of Medicine, Chicago

63110

Washington University St. Louis, St Louis

75246

Sammons Cancer Center, Dallas

77030

Baylor College of Medicine, Houston

MD Anderson Cancer Center, Houston

80045

University of Colorado Cancer Center, Aurora

80113

Western States Cancer Center, Englewood

85719

University of Arizona Cancer Center, Tucson

90401

John Wayne Cancer Institute / Providence St. John's Health Center, Santa Monica

92868

University of California Irvine, Orange

94185

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco

97239

Oregon Health and Science University, Portland

98109

University of Washington- Seattle Cancer Care Alliance, Seattle

02215

Dana Farber Cancer Institute, Boston

03756

Dartmouth-Hitchcock Medical Center, Lebanon

07652

Valley - Mount Sinai Comprehensive Cancer Center, Paramus

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Exicure, Inc.

INDUSTRY