290
Participants
Start Date
May 1, 2019
Primary Completion Date
July 31, 2026
Study Completion Date
March 31, 2027
Infusion of 5 mg/kg Infliximab
Infliximab is a prescription drug with marketing authorisation for the treatment of rheumatoid arthritis, Crohn's disease, ulcerative colitis, ankylosing spondylitis, psoriatic arthritis and psoriasis. In the RAPID-I trial infliximab will be used outside the manufacturer's indication for the treatment of AP, and it is classed as an investigational medicinal product (IMP).
Infusion of 10 mg/kg Infliximab
Infliximab is a prescription drug with marketing authorisation for the treatment of rheumatoid arthritis, Crohn's disease, ulcerative colitis, ankylosing spondylitis, psoriatic arthritis and psoriasis. In the RAPID-I trial infliximab will be used outside the manufacturer's indication for the treatment of AP, and it is classed as an investigational medicinal product (IMP).
0.9% Sodium Chloride (Placebo)
250 ml (500 ml if patient weighs over 100 kg) of 0.9% Sodium Chloride
RECRUITING
Aberdeen Royal Infirmary, Aberdeen
NOT_YET_RECRUITING
University Hospital of Wales, Cardiff
NOT_YET_RECRUITING
Royal Cornwall Hospital, Truro
NOT_YET_RECRUITING
Royal Devon and Exeter Hospital, Exeter
RECRUITING
University College London Hospital, London
SUSPENDED
St Mary's Hospital, London
SUSPENDED
Charing Cross Hospital, London
RECRUITING
Royal Liverpool University Hospital, Liverpool
RECRUITING
Aintree University Hospital, Liverpool
RECRUITING
Whiston Hospital, Whiston
RECRUITING
Queen's Medical Centre, Nottingham
RECRUITING
John Radcliffe Hospital, Oxford
NOT_YET_RECRUITING
St James's University Hospital, Leeds
Collaborators (1)
Bangor University
OTHER
Liverpool University Hospitals NHS Foundation Trust
OTHER_GOV
Medical Research Council
OTHER_GOV
National Institute for Health Research, United Kingdom
OTHER_GOV
Merck Sharp & Dohme LLC
INDUSTRY
University of Liverpool
OTHER