Randomised Treatment of Acute Pancreatitis With Infliximab: Double-blind, Placebo-controlled, Multi-centre Trial (RAPID-I)

PHASE2RecruitingINTERVENTIONAL
Enrollment

290

Participants

Timeline

Start Date

May 1, 2019

Primary Completion Date

July 31, 2026

Study Completion Date

March 31, 2027

Conditions
Acute Pancreatitis
Interventions
DRUG

Infusion of 5 mg/kg Infliximab

Infliximab is a prescription drug with marketing authorisation for the treatment of rheumatoid arthritis, Crohn's disease, ulcerative colitis, ankylosing spondylitis, psoriatic arthritis and psoriasis. In the RAPID-I trial infliximab will be used outside the manufacturer's indication for the treatment of AP, and it is classed as an investigational medicinal product (IMP).

DRUG

Infusion of 10 mg/kg Infliximab

Infliximab is a prescription drug with marketing authorisation for the treatment of rheumatoid arthritis, Crohn's disease, ulcerative colitis, ankylosing spondylitis, psoriatic arthritis and psoriasis. In the RAPID-I trial infliximab will be used outside the manufacturer's indication for the treatment of AP, and it is classed as an investigational medicinal product (IMP).

OTHER

0.9% Sodium Chloride (Placebo)

250 ml (500 ml if patient weighs over 100 kg) of 0.9% Sodium Chloride

Trial Locations (13)

AB25 2ZN

RECRUITING

Aberdeen Royal Infirmary, Aberdeen

CF14 4XW

NOT_YET_RECRUITING

University Hospital of Wales, Cardiff

TR1 3LJ

NOT_YET_RECRUITING

Royal Cornwall Hospital, Truro

EX2 5DW

NOT_YET_RECRUITING

Royal Devon and Exeter Hospital, Exeter

NW1 2BU

RECRUITING

University College London Hospital, London

W2 1NY

SUSPENDED

St Mary's Hospital, London

W6 8RF

SUSPENDED

Charing Cross Hospital, London

L7 8XP

RECRUITING

Royal Liverpool University Hospital, Liverpool

L9 7AL

RECRUITING

Aintree University Hospital, Liverpool

L35 5DR

RECRUITING

Whiston Hospital, Whiston

NG7 2UH

RECRUITING

Queen's Medical Centre, Nottingham

OX3 9DU

RECRUITING

John Radcliffe Hospital, Oxford

LS9 7TF

NOT_YET_RECRUITING

St James's University Hospital, Leeds

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bangor University

OTHER

collaborator

Liverpool University Hospitals NHS Foundation Trust

OTHER_GOV

collaborator

Medical Research Council

OTHER_GOV

collaborator

National Institute for Health Research, United Kingdom

OTHER_GOV

collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

University of Liverpool

OTHER