IPD in RRMM Characterized with Genomic Abnormalities of Adverse Prognostic

PHASE2TerminatedINTERVENTIONAL
Enrollment

26

Participants

Timeline

Start Date

November 3, 2019

Primary Completion Date

December 31, 2022

Study Completion Date

February 10, 2023

Conditions
Multiple MyelomaRelapsed and Refractory Multiple MyelomaGenetic Condition
Interventions
DRUG

Ixazomib/Pomalidomide/Dexamethasone

"Treatment with association of Ixazomib, Pomalidomide and Dexamethasone (IPD)~Induction phase : 21-days cycles - maximum of 17 cycles Ixazomib (tablets) 3 mg D1, D4, D8 and D11 Pomalidomide (tablets) 4mg D1 to D14 Dexamethasone (tablets) 40 mg/d D1, D8 and D15 if patient aged \<75 years Dexamethasone (tablets) 20 mg/d D1, D8 and D15 if patient aged ≥ 75 years~Treatment with association of Ixazomib and Pomalidomide (IP) Maintenance phase : 28-days cycles until disease progression Ixazomib (tablets) 4mg D1, D8 and D15 Pomalidomide (tablets) 4mg D1 to D21"

Trial Locations (28)

14033

CHU de Caen, Caen

21000

CHU de Dijon, Dijon

24019

Centre Hospitalier de Périgueux, Périgueux

31059

Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse

33604

CHU Bordeaux - Hôpital Haut Leveque, Pessac

34295

CHU Saint Eloi, Montpellier

35033

CHU Pontchaillou, Rennes

35510

Hôpital Privé Sévigné, Cesson-Sévigné

37044

CHRU Bretonneau, Tours

38043

CHU de Grenoble, Grenoble

44035

CHRU Hôtel Dieu, Nantes

49033

CHU Angers, Angers

51092

CHU de Reims Hôpital Robert Debré, Reims

54511

Hôpitaux de Brabois - CHRU de Nancy, Vandœuvre-lès-Nancy

59037

CHRU Hôpital Claude Huriez, Lille

59386

Centre hospitalier de Dunkerque, Dunkirk

64109

Centre hospitalier de la côte basque, Bayonne

67091

Institut de cancérologie Strasbourg Europe (ICANS), Strasbourg

69495

Centre Hospitalier Lyon Sud, Pierre-Bénite

75475

Hôpital Saint Louis, Paris

76038

Centre Henri Becquerel, Rouen

84000

CH Avignon - Centre Hospitalier H.Duffaut, Avignon

85925

Centre hospitalier départemental de Vendée, La Roche-sur-Yon

86021

CHU de Poitiers, Poitiers

87042

CHU de Limoges, Limoges

93009

Hôpital Avicenne, Bobigny

94010

CHU Henri Mondor, Créteil

06202

Hôpital de l'Archet 1, Nice

All Listed Sponsors
collaborator

AXONAL

UNKNOWN

collaborator

Nantes University Hospital

OTHER

collaborator

University Hospital, Grenoble

OTHER

collaborator

Euraxi Pharma

INDUSTRY

collaborator

QPS Holdings LLC

INDUSTRY

collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

Takeda

INDUSTRY

lead

Intergroupe Francophone du Myelome

NETWORK

NCT03683277 - IPD in RRMM Characterized with Genomic Abnormalities of Adverse Prognostic | Biotech Hunter | Biotech Hunter