Reversal of Atrial Substrate to Prevent Atrial

NARecruitingINTERVENTIONAL
Enrollment

670

Participants

Timeline

Start Date

July 1, 2019

Primary Completion Date

June 30, 2025

Study Completion Date

June 30, 2027

Conditions
Atrial Fibrillation
Interventions
OTHER

Aggressive Risk Factor Control

"1. Sleep apnea screening, therapy is recommended if apopnea-hypopnea (AHI) index is greater than 15, with a target index of less than 5.~2. Counseling regarding alcohol reduction to 2 drinks/day for men, 1 drink/day for women, no binge drinking (\>5 drinks at one setting).~3. Participation in a 12 week structured, home-based exercise program and nutritional counseling. Weight reduction will be emphasized through modification of diet and exercise.~4. Blood Pressure management to achieve a target systolic blood pressure (SBP) of \<120/80 mm/Hg~5. Smoking cessation facilitated through local resources already established at each site"

OTHER

Standard of Care

Recommendations based on current guidelines

Trial Locations (17)

Unknown

RECRUITING

Foothills Hospital, Calgary

RECRUITING

Mazankowski Alberta Heart Institute, Edmonton

RECRUITING

Kelowna General Health, Kelowna

ACTIVE_NOT_RECRUITING

St. Paul's Hospital, Vancouver

RECRUITING

Saint John Regional Hospital, Saint John

RECRUITING

Hamilton Health Sciences Center, Hamilton

RECRUITING

St. Mary's General Hospital, Kitchener

RECRUITING

London Health Sciences Center, London

RECRUITING

Ottawa Heart Institute, Ottawa

RECRUITING

St. Michael's Hospital, Toronto

RECRUITING

Sunnybrook Health Sciences Centre, Toronto

COMPLETED

Laval Hospital, Laval

ACTIVE_NOT_RECRUITING

McGill University Health Centre, Montreal

RECRUITING

Montreal Heart Institute, Montreal

RECRUITING

Sacre Coeur Hospital, Montreal

RECRUITING

Regina General Hospital, Regina

B3H 3A7

RECRUITING

QE II Health Sciences Centre, Halifax

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Canadian Institutes of Health Research (CIHR)

OTHER_GOV

collaborator

Abbott

INDUSTRY

collaborator

Phillips

UNKNOWN

collaborator

Cardiac Arrhythmia Network of Canada

OTHER

lead

Nova Scotia Health Authority

OTHER

NCT03682991 - Reversal of Atrial Substrate to Prevent Atrial | Biotech Hunter | Biotech Hunter