9-ING-41 in Patients with Advanced Cancers

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

350

Participants

Timeline

Start Date

January 4, 2019

Primary Completion Date

January 31, 2025

Study Completion Date

January 31, 2026

Conditions
CancerPancreatic CancerSarcomaRenal CancerRefractory CancerRefractory NeoplasmRefractory Non-Hodgkin LymphomaPancreatic AdenocarcinomaResistant CancerNeoplasm MetastasisNeoplasm of BoneNeoplasm, BreastNeoplasm of LungNeoplasms,ColorectalNeoplasms PancreaticMalignant GliomaMalignanciesMalignancies MultipleBone MetastasesBone NeoplasmBone CancerPancreas CancerPancreatic NeoplasmsBreast NeoplasmsAcute T Cell Leukemia Lymphoma
Interventions
DRUG

9-ING-41

Starting dose of-9-ING-41 will be administered on Day 1 and 4 each week of a 21-day cycle. 9-ING-41 will be administered intravenously over 60 minutes.

DRUG

Gemcitabine - 21 day cycle

Gemcitabine 1250 mg/m2 as a 30-minute intravenous infusion on Days 1 and 8 of a 21-day cycle

DRUG

Doxorubicin.

Doxorubicin 75 mg/m2, intravenous bolus on Day 1 of a 21-day cycle up to a maximum lifetime dose of 550 mg/m2.

DRUG

Lomustine

Lomustine 30 mg/m² orally as a single dose, weekly for twelve weeks.

DRUG

Carboplatin.

Carboplatin AUC 6 IV over 1 hour on Day 1 of a 21-day cycle.

DRUG

Nab paclitaxel.

Nab-paclitaxel 125 mg/m2 intravenously on Days 1, 8 and 15 of a 28-day cycle

DRUG

Paclitaxel.

Paclitaxel 175 mg/m2 intravenously over 3 hours on Day 1 of a 21-day cycle.

DRUG

Gemcitabine - 28 day cycle

Gemcitabine 1000 mg/m2 intravenously over 30-minutes on Days 1, 8 and 15 of a 28-day cycle

DRUG

Irinotecan

Irinotecan 350 mg/m2 intravenously over 90-minutes on Day 1 of a 21-day cycle

Trial Locations (66)

2650

UZA- Antwerpen, Edegem

2820

Imelda VZW, Bonheiden

3000

UZ Leuven Gasthuisberg, Leuven

8908

Institut Catala d'Oncologia, Barcelona

9000

UZ Gent, Ghent

10032

Columbia University- Irving Medical Center, New York

11794

Stony Brook University Hospital, Stony Brook

13005

Hopital de la Timone, Marseille

15212

Allegheny Health Network, Pittsburgh

18015

St. Luke's University Health Network, Bethlehem

19709

Christiana Care Health Services, Newark

20016

Sibley Memorial Hospital, Washington D.C.

25030

Center Hospitalier Regional Universitaire de Besancon - Site Jean Minjoz, Besançon

26506

West Virginia University, Morgantown

26905

Prisma Health Cancer Institute, Greenville

27710

Duke University Medical Center, Durham

28050

Hospital Clinico U San Carlos (HSC), Madrid

START Madrid-HM CIOCC Hospital Universitario, Madrid

29200

CHRU Brest Hopital Morvan, Brest

33076

Institut Bergonie, Bordeaux

33176

Miami Cancer Institute, Miami

33705

Florida Cancer Specialists - North, St. Petersburg

33901

Florida Cancer Specialists - South, Fort Myers

37203

Sarah Cannon Research Institute- Tennessee Oncology-Nashville, Nashville

37232

Vanderbilt-Ingram Cancer Center, Nashville

38120

Baptist Clinical Research Institute, Memphis

38138

West Cancer Center, Germantown

44800

Insitut de Cancerologie de l'Ouest, Saint-Herblain

46010

INCLIVA University of Valencia, Valencia

48109

University of Michigan, Ann Arbor

50309

Des Moines Oncology Research Association, Des Moines

53792

UW Carbone Cancer Center, Madison

54500

Institute de Cancerologie de Lorraine, Vandœuvre-lès-Nancy

55416

MetroMetro-Minnesota Community Oncology Research Consortium (MMCORC), Minneapolis

55905

Mayo Clinic, Rochester

57105

Sanford Research, Sioux Falls

59037

Hopital Claude Huriez, Lille

60611

Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago

66160

Kansas University Cancer Center, Kansas City

70121

Ochsner Clinic Foundation, New Orleans

75246

Texas Oncology- Charles A. Sammons Cancer Center, Dallas

75390

UT Southwestern Medical Center, Dallas

84124

Utah Cancer Specialists, Salt Lake City

85054

Mayo Clinic, Phoenix

85704

Arizona Oncology Associates, Tucson

85719

The University of Arizona Cancer Center, Tucson

89128

Comprehensive Cancer Centers of Nevada, Las Vegas

92868

University of California Irvine Health, Orange

94115

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco

97239

Oregon Health and Science University, Portland

98109

Fred Hutchinson Cancer Research Center, Seattle

07960

Morristown Medical Center, Morristown

08534

Capital Health Medical Center/ Hopewell, Pennington

08043

MD Anderson Cancer Center at Cooper, Voorhees Township

02903

Rhode Island Hospital, Providence

T6G 1Z2

Cross Cancer Institute, Edmonton

B3H 2Y9

QE II Health Sciences Centre, Halifax

G4V 2H1

Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre, Greenfield Park

H3T 1E2

Jewish General Hospital, Montreal

H4A 3J1

McGill University Health Centre, Montreal

J1H 5N4

Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke

1066 CX

Netherlands Cancer Institute, Amsterdam

1400-038

Fundacao Champalimaud, Lisbon

1500-650

Hospital Da Luz, Lisbon

4200-319

Centro Hospitalar Universitario Sao Joao, Porto

08035

Vall d'Hebron Institute of Oncology, Barcelona

Sponsors
All Listed Sponsors
lead

Actuate Therapeutics Inc.

INDUSTRY