Study Evaluating Safety and Efficacy of CAR-T Cells Targeting CD123 in Patients With Acute Leukemia

PHASE1TerminatedINTERVENTIONAL
Enrollment

2

Participants

Timeline

Start Date

April 17, 2019

Primary Completion Date

July 31, 2019

Study Completion Date

July 31, 2019

Conditions
Acute LeukemiaAcute Leukemia in RelapseAcute Myeloid LeukemiaRelapsed or Refractory Acute Leukemia
Interventions
DRUG

anti-CD123 CAR-T treatment

Patients receive fludarabine phosphate(300 mg/m\^2) and cyclophosphamide (30 mg/m\^2) IV on days -5 to -3, and then Patients receive autologous anti-CD123 CAR T cells IV over 20 minutes on day 0 (20% of total dose), day2 (30% of total dose) and day6 (50% of total dose, according to the side-effects occured). The total dose of CAR-T cells used in dose-escalation study is 0.5x10\^6- 2.0x10\^6 CAR-T cells/kg.

Trial Locations (1)

710000

Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an

Sponsors
All Listed Sponsors
collaborator

Nanjing Legend Biotech Co.

INDUSTRY

lead

Second Affiliated Hospital of Xi'an Jiaotong University

OTHER