A Study to Evaluate the Safety and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With Polatuzumab Vedotin in B-Cell Non-Hodgkin Lymphoma

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

422

Participants

Timeline

Start Date

September 25, 2018

Primary Completion Date

January 30, 2024

Study Completion Date

July 20, 2025

Conditions
B-cell Non-Hodgkin Lymphoma
Interventions
DRUG

Mosunetuzumab (IV)

Participants will receive intravenous (IV) mosunetuzumab.

DRUG

Mosunetuzumab (SC)

Participants will receive subcutaneous (SC) mosunetuzumab.

DRUG

Polatuzumab vedotin

Participants will receive IV polatuzumab vedotin.

DRUG

Tocilizumab

Participants will receive IV tocilizumab as needed.

DRUG

Rituximab

Participants will receive IV rituximab.

Trial Locations (29)

1090

UZ Brussel, Brussels

1340

Clinique St Pierre asbl, Ottignies

7100

CH Jolimont - Lobbes (Jolimont), Haine-Saint-Paul

10003

Hospital de San Pedro de Alcantara, Cáceres

10016

New York University Langone Medical Center, New York

17033

Penn State Milton S. Hershey Medical Center, Hershey

19111

Fox Chase Cancer Center, Philadelphia

28007

Hospital General Universitario Gregorio Marañon, Madrid

28031

Hospital Infanta Leonor; Servicio de Hematologia, Madrid

28204

Levine Cancer Institute, Charlotte

33136

University of Miami Miller School of Medicine, Miami

33612

Moffitt Cancer Center, Tampa

35249

University of Alabama at Birmingham School of Medicine, Birmingham

41009

Hospital Universitario Virgen Macarena; Servicio de Oncologia, Seville

48109

University of Michigan Hospital, Ann Arbor

48201

Karmanos Cancer Institute, Detroit

53226

Medical College of Wisconsin, Froedtert Hospital;Nephrology Section, Milwaukee

77030

University of Texas M.D. Anderson Cancer Center, Houston

80045

University of Colorado Hospital - Anschutz Cancer Pavilion, Aurora

91010

City of Hope, Duarte

98109

Fred Hutchinson Cancer Research Center, Seattle

15232-1301

University of Pittsburgh - Hillman Cancer Center, Pittsburgh

02905

Lifespan Cancer Institute, Providence

L8V 5C2

Hamilton Health Sciences - Juravinski Cancer Centre, Hamilton

H3T 1E2

Jewish General Hospital, Montreal

S7N 4H4

Saskatchewan Cancer Agency (SCA) - Saskatoon Cancer Centre (SCC), Saskatoon

08908

Institut Catala d Oncologia Hospital Duran i Reynals, Barcelona

CB2 0QQ

Cambridge University Hospitals NHS Foundation Trust, Cambridge

PL6 8DH

Plymouth Hospitals NHS Trust; Pharmacy Dept, Plymouth

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT03671018 - A Study to Evaluate the Safety and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With Polatuzumab Vedotin in B-Cell Non-Hodgkin Lymphoma | Biotech Hunter | Biotech Hunter