Tight Versus Liberal Blood Glucose Control in Adult Critically Ill Patients

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

9,230

Participants

Timeline

Start Date

September 18, 2018

Primary Completion Date

November 30, 2022

Study Completion Date

November 30, 2026

Conditions
Critical IllnessHyperglycemia
Interventions
DRUG

Insulin

When blood glucose exceeds the preset target, insulin will be administered through continuous intravenous infusion. Insulin will be titrated according to frequent measurement of blood glucose and with use of the LOGIC-insulin algorithm in the experimental group. The intervention will be stopped upon ICU discharge, or until the patient is able to resume oral feeding, or until the patient no longer has a central venous catheter, whatever comes first.

Trial Locations (4)

3000

Department of Intensive Care Medicine, University Hospitals Leuven, Leuven

Medical Intensive Care Unit, University Hospitals Leuven, Leuven

3500

Department of Intensive Care Medicine, Jessa Hospital Hasselt, Hasselt

9000

Department of Intensive Care Medicine, University Hospital Ghent, Ghent

All Listed Sponsors
collaborator

Universitaire Ziekenhuizen KU Leuven

OTHER

collaborator

Research Foundation Flanders

OTHER

lead

KU Leuven

OTHER