to Evaluate the Efficacy and Safety of Eltrombopag for Immune Thrombocytopenia With Chronic HBV Infection

PHASE2CompletedINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

December 4, 2018

Primary Completion Date

June 30, 2022

Study Completion Date

September 30, 2022

Conditions
Thrombocytopenia PurpuraChronic HBV Infection
Interventions
DRUG

Eltrombopag

subjects will initiate treatment with 25 mg eltrombopag. Platelet counts is obtained weekly and dose adjustment should be done according to platelet counts. and maximum dose should not exceed 75 mg daily. Subjects whose platelet count between 50\~150×109/L,the eltrombopag dose Maintain. platelet count between 150\~250×109/L, need to reduce the dose of eltrombopag to the next lower dose or lower frequency. Subjects whose platelet count exceeds 250×109/L at any point during the treatment period, must have eltrombopag interrupted and increase the frequency of platelet monitoring to twice weekly, until platelet counts fall below 100×109/L.

Trial Locations (1)

300020

Ethics Committee of Blood disease hospital, Chinese Academy of Medical Sciences, Tianjin

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Novartis

INDUSTRY

collaborator

Qilu Hospital of Shandong University

OTHER

collaborator

The Second Affiliated Hospital of Kunming Medical University

OTHER

collaborator

Tianjin First Central Hospital

OTHER

collaborator

Tianjin Medical University Second Hospital

OTHER

collaborator

Henan Cancer Hospital

OTHER_GOV

collaborator

The Second Hospital of Hebei Medical University

OTHER

collaborator

North China University of Science and Technology

OTHER

collaborator

The Affiliated Hospital of Qingdao University

OTHER

collaborator

The First Affiliated Hospital of University of Science and Technology of China

OTHER

collaborator

The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

OTHER

collaborator

Second Affiliated Hospital of Guangzhou Medical University

OTHER

lead

Institute of Hematology & Blood Diseases Hospital, China

OTHER