Mesothelioma Stratified Therapy (MiST) : A Multi-drug Phase II Trial in Malignant Mesothelioma

PHASE2UnknownINTERVENTIONAL
Enrollment

186

Participants

Timeline

Start Date

January 28, 2019

Primary Completion Date

October 31, 2023

Study Completion Date

October 31, 2023

Conditions
Mesothelioma, Malignant
Interventions
DRUG

Rucaparib

PARP inhibitor

DRUG

Abemaciclib

CDK4/6 inhibitor

DRUG

pembrolizumab & bemcentinib

PD1 checkpoint inhibitor, AXL inhibitor

DRUG

Atezolizumab & Bevacizumab

PDL1 checkpoint inhibitor, VEGF inhibitor

DRUG

Dostarlimab and Niraparib

IG Antibody, PARP Inhibitor

Trial Locations (1)

LE1 5WW

University Hospitals of Leicester NHS Trust, Leicester

All Listed Sponsors
collaborator

British Lung Foundation

OTHER

collaborator

Clovis Oncology, Inc.

INDUSTRY

collaborator

Eli Lilly and Company

INDUSTRY

collaborator

Merck Sharp & Dohme LLC

INDUSTRY

collaborator

BerGenBio ASA

INDUSTRY

collaborator

Roche Pharma AG

INDUSTRY

collaborator

University Hospitals, Leicester

OTHER

collaborator

The Christie NHS Foundation Trust

OTHER

collaborator

GlaxoSmithKline

INDUSTRY

lead

University of Leicester

OTHER