Screening and Multiple Intervention on Lung Epidemics

"Cytisine administration will be randomized 1:1 in standard (40 days)and prolonged treatment (84 days).~Subjects will be educated on how to take the product and informed about possible adverse effects."

The treatment will consist of Acetylsalicylic acid at 100mg once a day

"It will be proposed:~1. an optimal diet with the aim of favoring control of weight, abdominal fat and adequate nutritional status without increasing the levels of IGF-I and inflammatory factors or glycemic peaks, with periodic verification of the results~2. a regular and sustainable physical activity program with periodic verification of the results."

standard treatment for early lung cancer detection with ultra low dose CT

spirometry with CO test

anthropometic data collection

blood test to assess the metabolic and inflammatory profile