A Study to Assess the Safety, Tolerability, and Efficacy of BIVV003 for Autologous Hematopoietic Stem Cell Transplantation in Patients With Severe Sickle Cell Disease

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

7

Participants

Timeline

Start Date

March 6, 2019

Primary Completion Date

July 17, 2025

Study Completion Date

July 17, 2025

Conditions
Sickle Cell Disease
Interventions
BIOLOGICAL

Plerixafor

Plerixafor subcutaneous injection will be administered prior to apheresis.

DRUG

Busulfan

Busulfan IV infusion will be administered as myeloablative conditioning therapy.

GENETIC

BIVV003

BIVV003 will be administered as an IV infusion following myeloablative conditioning with busulfan.

Trial Locations (5)

20892

Investigational Site Number 101, Bethesda

30322

Children's Healthcare of Atlanta, Atlanta

48201

Karmanos Cancer Institute, Detroit

94609

UCSF Benioff Children's Hospital, Oakland

95817

University of California Davis Comprehensive Cancer Center, Sacramento

Sponsors
All Listed Sponsors
lead

Sangamo Therapeutics

INDUSTRY