Multi-antigen T Cell Infusion Against Neuro-oncologic Disease

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

33

Participants

Timeline

Start Date

December 12, 2018

Primary Completion Date

March 31, 2028

Study Completion Date

December 31, 2028

Conditions
Brain Tumor
Interventions
BIOLOGICAL

TAA-T

Patients with newly diagnosed diffuse intrinsic pontine gliomas DIPGs (Group A) or recurrent, progressive, or refractory non-brainstem CNS malignancies (Group B). The goal of this cell infusion will be to initiate an immune response against brain tumors that includes multiple antigens and may prevent tumor evasion (through decreased expression of a single antigen)

Trial Locations (1)

20010

Brain Tumor Institute, Children's National Medical Center, Washington D.C.

All Listed Sponsors
collaborator

Children's National Research Institute

OTHER

lead

Catherine Bollard

OTHER