A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo.

PHASE2CompletedINTERVENTIONAL
Enrollment

99

Participants

Timeline

Start Date

October 29, 2018

Primary Completion Date

March 2, 2022

Study Completion Date

March 30, 2022

Conditions
Alpha 1-Antitrypsin DeficiencyEmphysemaCOPD
Interventions
DRUG

Placebo Oral Tablet

twice daily administration

DRUG

Alvelestat oral tablet - dose 1

twice daily administration

DRUG

Alvelestat oral tablet - dose 2

twice daily administration

Trial Locations (26)

2900

Gentofte Hospital, Hellerup

3000

UZ Leuven, Leuven

5000

Synddansk Universitet (SDU) - Odense University, Odense

8200

Aarhus Universitetshospital, Aarhus

9000

UZ Gent, Ghent

22185

Lund University Hospital, Lund

28401

PMG Research of Wilmington, Wilmington

35294

University of Alabama, Birmingham (UAB), Birmingham

41345

CTC Gothia Forum Sahlgrenska University Hospital, Gothenburg

90095

UCLA Medical Center, Los Angeles

95817

UC Davis Medical Centre, Sacramento

T6G 2C8

The University Lung Clinic, Edmonton

V6Z 1Y6

Centre for Heart Lung Innovation, St Pauls Hospital, Vancouver

M5T 3A9

Inspiration Research Ltd, Toronto

S7N 0W8

University of Saskatchewan Royal University Hospital, Saskatoon

01-138

Instytut Gruzilicy Chorob Pluc, Warsaw

Unknown

Hospital Univ Clinico San Carlos, Madrid

Hospital Sierrallana, Torrelavega

B15 2GW

University Hospitals Birmingham NHS Foundation Trust, Birmingham

CB2 0QQ

Cambridge University Hospitals Foundation NHS Trust, Cambridge

CV2 2DX

University Hospital Coventry and Warwickshire, Coventry

EH16 4TJ

Royal Infirmary of Edinburgh, Edinburgh

PhD

Royal Devon and Exeter NHS Trust, Exeter

LE1 7RH

University Hospitals of Leicester NHS Trust, Leicester

SWP 6NP

Royal Brompton Hospital, London

SO16 6YD

Southampton General Hospital, Southampton

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Syneos Health

OTHER

lead

Mereo BioPharma

INDUSTRY

NCT03636347 - A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo. | Biotech Hunter | Biotech Hunter