Evaluation of NanoDoce® in Participants With Urothelial Carcinoma

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

36

Participants

Timeline

Start Date

April 2, 2019

Primary Completion Date

November 2, 2021

Study Completion Date

November 2, 2021

Conditions
Bladder CancerUrothelial CarcinomaUrinary Bladder NeoplasmUrinary Bladder CancerUrogenital NeoplasmsUrologic NeoplasmsUrologic CancerMalignant Tumor of the Urinary BladderCancer of the Bladder
Interventions
DRUG

NanoDoce (direct injection)

Subjects will receive NanoDoce injected into the index tumor resection site on the bladder wall, immediately following transurethral resection of the bladder tumor (TURBT)

DRUG

NanoDoce (intravesical instillation) - Visit 2 Instillation

All subjects will receive an initial intravesical instillation within 2 hours of direct injection.

OTHER

Institutional Standard of Care

Group 2 (MIBC) will receive institutional standard of care treatments after the Visit 2 intravesical instillation.

DRUG

NanoDoce (intravesical instillation) - Induction and Maintenance Instillations

Group 1 (NMIBC) will receive intravesical instillations in an Induction Period and a Maintenance Period.

Trial Locations (5)

10032

Columbia University Herbert Irving Comprehensive Cancer Center, New York

21287

James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore

29572

Carolina Urologic Research Center, Myrtle Beach

78229

UT Health San Antonio, San Antonio

85032

BCG Oncology, PC, Phoenix

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

US Biotest, Inc.

INDUSTRY

lead

NanOlogy, LLC

INDUSTRY

NCT03636256 - Evaluation of NanoDoce® in Participants With Urothelial Carcinoma | Biotech Hunter | Biotech Hunter