Dose-Escalated Proton Radiation Therapy for High-Risk Prostate Cancer

NAActive, not recruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

September 24, 2018

Primary Completion Date

September 30, 2028

Study Completion Date

September 30, 2028

Conditions
Adenocarcinoma of the Prostate
Interventions
RADIATION

HR-A

"The prostate and proximal seminal vesicles will be treated to 2 cobalt gray equivalent per fraction for 39 fractions for a total of 78 cobalt gray equivalent.~Simultaneous integrated boost to the IPT will be delivered to 2.2 cobalt gray equivalent per fraction for 39 fractions for a total of 85.8 cobalt gray equivalent.~Treatment will be given once a day, approximately 5 treatments per week (Monday- Friday), over 8-9 weeks."

RADIATION

HR-B

"The prostate, proximal seminal vesicles, and pelvic nodes will be treated to 2 cobalt gray equivalent per fraction for 23 fractions for a total of 46 cobalt gray equivalent.~The prostate and proximal seminal vesicles will be treated to an additional 2 cobalt gray equivalent per fraction for 16 fractions for a total of 32 cobalt gray equivalent.~Electively treat the entire uninvolved seminal vesicle to 2 cobalt gray equivalent per fraction for 39 fractions for a total of 78 cobalt gray equivalent when part of the seminal vesicle is involved with tumor.~Simultaneous integrated boost to the IPT will be delivered to 2.2 cobalt gray equivalent per fraction for 39 fractions for a total of 85.8 cobalt gray equivalent.~Treatment will be given once a day, approximately 5 treatments per week (Monday- Friday), over 8-9 weeks."

Trial Locations (1)

32206

University of Florida Health Proton Therapy Institute, Jacksonville

All Listed Sponsors
lead

University of Florida

OTHER

NCT03624660 - Dose-Escalated Proton Radiation Therapy for High-Risk Prostate Cancer | Biotech Hunter | Biotech Hunter