Postoperative Concurrent Chemoradiotherapy Combined With Endostar for High-risk Early Stage Cervical Cancer

PHASE2UnknownINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

July 31, 2018

Primary Completion Date

July 30, 2023

Study Completion Date

July 30, 2025

Conditions
Uterine Cervical Neoplasms
Interventions
COMBINATION_PRODUCT

Chemoradiotherapy+ Endostar

"Chemoradiotherapy with Endostar:~* Chemoradiotherapy: pelvic radiotherapy starts 2-3 weeks after surgery. Intensity modulated radiotherapy (IMRT) is given five fractions per week at 1.8-2 Gy/fraction/day with total dose summed up to 45-50Gy. The external beam radiotherapy should be completed within 6 weeks.~* Concurrent chemotherapy is consisted of cisplatin (75 mg/m2, day 1-3) and 5-fluorouracil (5-FU; 1000mg/m2/day, civ, day 1-4) for 2 cycles every 3 weeks.~* Endostar: recombinant human endostatin (15mg/m2/d, civ, d1-7) is given 3 days before the concurrent chemoradiotherapy for 2 cycles every 3 weeks."

Trial Locations (1)

215001

RECRUITING

The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou

Sponsors
All Listed Sponsors
collaborator

Second Affiliated Hospital of Soochow University

OTHER

lead

Nanjing Medical University

OTHER