120
Participants
Start Date
July 31, 2018
Primary Completion Date
July 30, 2023
Study Completion Date
July 30, 2025
Chemoradiotherapy+ Endostar
"Chemoradiotherapy with Endostar:~* Chemoradiotherapy: pelvic radiotherapy starts 2-3 weeks after surgery. Intensity modulated radiotherapy (IMRT) is given five fractions per week at 1.8-2 Gy/fraction/day with total dose summed up to 45-50Gy. The external beam radiotherapy should be completed within 6 weeks.~* Concurrent chemotherapy is consisted of cisplatin (75 mg/m2, day 1-3) and 5-fluorouracil (5-FU; 1000mg/m2/day, civ, day 1-4) for 2 cycles every 3 weeks.~* Endostar: recombinant human endostatin (15mg/m2/d, civ, d1-7) is given 3 days before the concurrent chemoradiotherapy for 2 cycles every 3 weeks."
RECRUITING
The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou
Lead Sponsor
Second Affiliated Hospital of Soochow University
OTHER
Nanjing Medical University
OTHER