Phase II Study of Second- Line Pembrolizumab Plus GVD for Relapsed or Refractory Hodgkin Lymphoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

257

Participants

Timeline

Start Date

August 1, 2018

Primary Completion Date

August 31, 2026

Study Completion Date

August 31, 2026

Conditions
Hodgkin LymphomaRelapsed or Refractory Hodgkin Lymphoma
Interventions
DRUG

pembrolizumab

Age 10-17: 2mg/kg (cap at 200mg), Age ≥ 18: 200 mg (flat) ,Day 1 of each 3 week cycle IV infusion 2-4 cycles (pre-ASCT)

DRUG

gemcitabine

1000mg/m\^2 Days 1 and 8 of each 3 week cycle IV infusion 2-4 cycles

DRUG

vinorelbine

20mg/m\^2 Days 1 and 8 of each 3 week cycle IV infusion 2-4 cycles

DRUG

liposomal doxorubicin

15mg/m\^2 Days 1 and 8 of each 3 week cycle IV infusion 2-4 cycles

PROCEDURE

Stem cell mobilization and collection

Stem cell mobilization and collection will be performed as per standard MSKCC guidelines after 2-4 cycles of pembrolizumab-GVD.

Trial Locations (8)

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10604

RECRUITING

Memorial Sloan Kettering Westchester, Harrison

11553

RECRUITING

Memorial Sloan Kettering Nassau, Uniondale

11725

RECRUITING

Memorial Sloan Kettering Cancer Center @ Commack, Commack

33136

RECRUITING

University of Miami, Miami

07920

RECRUITING

Memorial Sloan Kettering Basking Ridge, Basking Ridge

07748

RECRUITING

Memorial Sloan Kettering Monmouth, Middletown

07645

RECRUITING

Memorial Sloan Kettering Bergen, Montvale

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Memorial Sloan Kettering Cancer Center

OTHER

NCT03618550 - Phase II Study of Second- Line Pembrolizumab Plus GVD for Relapsed or Refractory Hodgkin Lymphoma | Biotech Hunter | Biotech Hunter