Study of AZD9833 Alone or in Combination in Women With Advanced Breast Cancer.

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

396

Participants

Timeline

Start Date

October 11, 2018

Primary Completion Date

September 16, 2024

Study Completion Date

December 31, 2026

Conditions
ER+ HER2- Advanced Breast Cancer
Interventions
DRUG

AZD9833

Part A: AZD9833 monotherapy dose escalation.

DRUG

AZD9833

Part B: AZD9833 monotherapy expansion.

DRUG

AZD9833 with palbociclib

Part C: AZD9833 in combination with palbociclib dose escalation

DRUG

AZD9833 with palbociclib

Part D: AZD9833 in combination with palbociclib expansion

DRUG

AZD9833 with everolimus

Part E: AZD9833 in combination with everolimus dose escalation

DRUG

AZD9833 with everolimus

Part F: AZD9833 in combination with everolimus dose expansion

DRUG

AZD9833 with abemaciclib

Part G: AZD9833 in combination with abemaciclib (± anastrozole) dose escalation

DRUG

AZD9833 with abemaciclib

Part H: AZD9833 in combination with abemaciclib (± anastrozole) dose expansion

DRUG

AZD9833 with capivasertib

Part I: AZD9833 in combination with capivasertib dose escalation

DRUG

AZD9833 with capivasertib

Part J: AZD9833 in combination with capivasertib dose expansion

DRUG

AZD9833 with ribociclib

Part K: AZD9833 in combination with ribociclib (± anastrozole) dose escalation

DRUG

AZD9833 with ribociclib

Part L: AZD9833 in combination with ribociclib (± anastrozole) dose expansion

DRUG

AZD9833 with anastrozole

Part M: AZD9833 in combination with anastrozole dose escalation

DRUG

AZD9833 with anastrozole

Part N: AZD9833 in combination with anastrozole dose expansion

Trial Locations (17)

8036

Research Site, Barcelona

19111

Research Site, Philadelphia

28041

Research Site, Madrid

28050

Research Site, Madrid

34232

Research Site, Sarasota

37203

Research Site, Nashville

41013

Research Site, Seville

46010

Research Site, Valencia

80045

Research Site, Aurora

84112

Research Site, Salt Lake City

08035

Research Site, Barcelona

CB2 0QQ

Research Site, Cambridge

LS9 7TF

Research Site, Leeds

SW2 6JJ

Research Site, London

M20 4GJ

Research Site, Manchester

SM1 2DL

Research Site, Sutton

SM2 5PT

Research Site, Sutton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY