Etokimab in Adults With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

PHASE2CompletedINTERVENTIONAL
Enrollment

105

Participants

Timeline

Start Date

November 29, 2018

Primary Completion Date

September 2, 2020

Study Completion Date

October 26, 2020

Conditions
Chronic Rhinosinusitis
Interventions
BIOLOGICAL

Etokimab

Administered by subcutaneous injection

BIOLOGICAL

Placebo

Administered by subcutaneous injection

DRUG

Mometasone Furoate Nasal Spray

Mometasone Furoate Nasal Spray (MFNS) was used from 4 weeks prior to Day 1 (Run-in period) through the end of the study. Participants used 2 actuations (50 μg/actuation) in each nostril BID, total daily dose of 400 μg. Participants intolerant to BID intranasal corticosteroids (INCS) could use the lower dose regimen of 1 actuation in each nostril BID, total daily dose of 200 μg.

Trial Locations (28)

10016

ENT and Allergy Associates ENTA LLP, New York

21236

Chesapeake Clinical Research Inc., Baltimore

23507

Eastern Virginia Medical School EVMS Medical Group, Norfolk

27599

University of North Carolina Hospitals, Chapel Hill

28105

Charlotte Eye Ear Nose and Throat Associates, Matthews

29420

National Allergy and Asthma Research, North Charleston

30024

Clinical Research Consultants of Atlanta, Suwanee

33175

Intermed Medical Research Center, Miami

34653

Advanced Research Institute, Inc., New Port Richey

40213

Advanced ENT and Allergy, Louisville

43016

Ohio Sinus Institute, Dublin

53228

Allergy, Asthma Sinus Center, SC, Greenfield

60657

Chicago ENT, Chicago

72209

Asthma & Allergy Institute, Little Rock

73120

Allergy Asthma Clinical Research Center, Oklahoma City

74136

Allergy Asthma and Immunology Center P.C., Tulsa

Central States Research, LLC, Tulsa

75070

Ear Nose and Throat Associates of Texas, McKinney

76109

Fort Worth ENT Berkson Medical, Fort Worth

80230

Colorado Allergy Asthma Centers, Denver

83706

Treasure Valley Medical Research, Boise

84020

Intermountain Ear Nose Throat Specialist, Draper

84790

Chrysalis Clinical Research, St. George

91304

Alliance Research Institute, Canoga Park

92123

Allergy & Asthma Medical Group and Research Center, San Diego

95661

DaVinci Research, Roseville

95815

Sacramento Ear Nose and Throat Surgical and Medical Group Inc. - SacENT, Sacramento

98225

Bellingham Asthma Allergy Immunology Clinic, Bellingham

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AnaptysBio, Inc.

INDUSTRY