A Phase 2 Study of Sitravatinib in Combination With PD-(L)1 Checkpoint Inhibitor Regimens in Patients With Advanced or Metastatic Urothelial Carcinoma

PHASE2TerminatedINTERVENTIONAL
Enrollment

260

Participants

Timeline

Start Date

September 11, 2018

Primary Completion Date

August 3, 2022

Study Completion Date

August 22, 2022

Conditions
Urothelial CarcinomaUrothelial Carcinoma BladderUrothelial Carcinoma UreterUrothelial Carcinoma of the Renal Pelvis and UreterUrothelial Carcinoma Urethra
Interventions
DRUG

Sitravatinib

Sitravatinib is a small molecule inhibitor of receptor tyrosine kinases

DRUG

Nivolumab

Nivolumab is a programmed death receptor-1 (PD-1) blocking antibody

DRUG

Pembrolizumab

Pembrolizumab is a programmed death receptor-1 (PD-1) blocking antibody

DRUG

Enfortumab vedotin

Enfortumab is a Nectin-4 directed antibody-drug conjugate (ADC) comprised of a monoclonal antibody conjugated to the small molecule microtubule disrupting agent, monomethyl auristatin E (MMAE)

Trial Locations (36)

10016

NYU Langone Laura & Isaac Perlmutter Cancer Center, New York

10065

Memorial Sloan-Kettering Cancer Center, New York

New York-Presbyterian - Weill Cornell Medical Center, New York

11042

Northwell Health Monter Cancer Center, Lake Success

12206

New York Oncology Hematology - Albany Medical Center, Albany

14263

Roswell Park Cancer Institute, Buffalo

15212

Allegheny General Hospital, Pittsburgh

20706

Maryland Oncology Hematology, P.A., Lanham

22031

Virginia Cancer Specialists- Fairfax, Fairfax

23502

Virginia Oncology Associates, Norfolk

27599

University of North Carolina - Lineberger Comprehensive Cancer Center, Chapel Hill

27710

Duke University Hospital, Durham

33401

SCRI - Florida Cancer Specialists - West Palm Beach, West Palm Beach

33612

Moffitt Cancer Center, Tampa

33705

SCRI - Florida Cancer Specialists- North Region, St. Petersburg

37232

Vanderbilt University - Ingram Cancer Center, Nashville

40202

Norton Cancer Institute - Broadway, Louisville

43202

The Ohio State University College of Medicine, Columbus

46202

Indiana University - Melvin & Bren Simon Cancer Center, Indianapolis

48201

Barbara Ann Karmanos Cancer Institute, Detroit

60637

The University of Chicago, Chicago

63110

Washington University School of Medicine - Siteman Cancer Center, St Louis

68130

GU Research Network/Urology Cancer Center, Omaha

70121

Ochsner Cancer Institute, New Orleans

75702

Texas Oncology - Tyler, Tyler

77024

Texas Oncology- Memorial City, Houston

77030

University of Texas - MD Anderson Cancer Center, Houston

78229

University of Texas Health Science Center, San Antonio

78731

Texas Oncology-Austin Central, Austin

80012

Rocky Mountain Cancer Centers, Aurora

85724

The University of Arizona Cancer Center, Tucson

89169

Comprehensive Cancer Centers of Nevada - Southwest, Las Vegas

92868

University of California Irvine, Irvine

98109

Seattle Cancer Center Alliance, Seattle

06510

Yale School of Medicine, New Haven

02215

Dana Farber Cancer Institute, Boston

Sponsors
All Listed Sponsors
lead

Mirati Therapeutics Inc.

INDUSTRY

NCT03606174 - A Phase 2 Study of Sitravatinib in Combination With PD-(L)1 Checkpoint Inhibitor Regimens in Patients With Advanced or Metastatic Urothelial Carcinoma | Biotech Hunter | Biotech Hunter