1,402
Participants
Start Date
October 11, 2018
Primary Completion Date
October 31, 2024
Study Completion Date
June 22, 2026
Niraparib
Participants will receive oral capsules of niraparib as a unit dosage strength of 100 milligrams (mg)
Dostarlimab (TSR-042)
Participants will receive 500 mg dostarlimab on day 1 every 3 weeks from cycle 2 to 6 followed by 1000mg of dostarlimab on day 1 every 6 weeks to continue up to 3 years in the absence of disease progression, unacceptable toxicity, participant withdrawal, or investigator decision
Standard of care
Participants will receive SOC that includes paclitaxel 175 milligrams per square meter (mg/m\^2) on day 1 every 21 days + carboplatin area under the curve (AUC) of 5 to 6 milligrams per milliliter per minute (mg/mL/min) on day 1 every 21 days +/- bevacizumab 7.5 milligrams per kilograms (mg/kg) every 21 days or 15 mg/kg every 21 days for a total of 15 months.
Dostarlimab-Placebo
Participants will receive 500 mg of dostarlimab-placebo on day 1 every 3 weeks from cycle 2 to 6 followed by 1000 mg of dostarlimab-placebo on day 1 every 6 weeks to continue up to 3 years in the absence of disease progression, unacceptable toxicity, participant withdrawal, or investigator decision
Niraparib-Placebo
Participants will receive oral capsules of niraparib-placebo as a unit dosage strength of 100 mg.
GSK Investigational Site, Windsor
GSK Investigational Site, Herlev
GSK Investigational Site, Brasschaat
GSK Investigational Site, Roskilde
GSK Investigational Site, Kristiansand
GSK Investigational Site, Bruges
GSK Investigational Site, Tromsø
GSK Investigational Site, New York
GSK Investigational Site, New York
GSK Investigational Site, New York
GSK Investigational Site, Hawthorne
GSK Investigational Site, Athens
GSK Investigational Site, Stony Brook
GSK Investigational Site, Athens
GSK Investigational Site, Haidari - Athens
GSK Investigational Site, Berlin
GSK Investigational Site, Syracuse
GSK Investigational Site, Marseille
GSK Investigational Site, Caen
GSK Investigational Site, Chernihiv
GSK Investigational Site, Marousi
GSK Investigational Site, Pittsburgh
GSK Investigational Site, Pittsburgh
GSK Investigational Site, Santiago de Compostela
GSK Investigational Site, Girona
GSK Investigational Site, Wynnewood
GSK Investigational Site, Philadelphia
GSK Investigational Site, Paoli
GSK Investigational Site, Turku
GSK Investigational Site, Silver Spring
GSK Investigational Site, Dijon
GSK Investigational Site, Baltimore
GSK Investigational Site, Plerin-sur-mer
GSK Investigational Site, Hamburg
GSK Investigational Site, Charlottesville
GSK Investigational Site, Jaén
GSK Investigational Site, Norfolk
GSK Investigational Site, Besançon
GSK Investigational Site, Madrid
GSK Investigational Site, Charlotte
GSK Investigational Site, Madrid
GSK Investigational Site, Charleston
GSK Investigational Site, Nîmes
GSK Investigational Site, Toulouse
GSK Investigational Site, Jacksonville
GSK Investigational Site, Gainesville
GSK Investigational Site, Bordeaux
GSK Investigational Site, Tampere
GSK Investigational Site, Montpellier
GSK Investigational Site, Montpellier
GSK Investigational Site, Rennes
GSK Investigational Site, Tours
GSK Investigational Site, Nashville
GSK Investigational Site, Nashville
GSK Investigational Site, Knoxville
GSK Investigational Site, Grenoble
GSK Investigational Site, Wolfsburg
GSK Investigational Site, Grenoble
GSK Investigational Site, Bologna
GSK Investigational Site, Saint-Priest-en-Jarez
GSK Investigational Site, Nantes
GSK Investigational Site, Canton
GSK Investigational Site, Toledo
GSK Investigational Site, Cincinnati
GSK Investigational Site, Valencia
GSK Investigational Site, Meldola FC
GSK Investigational Site, Faenza
GSK Investigational Site, Lugo RA
GSK Investigational Site, Münster
GSK Investigational Site, Angers
GSK Investigational Site, Reims
GSK Investigational Site, Nancy
GSK Investigational Site, Maplewood
GSK Investigational Site, Minneapolis
GSK Investigational Site, Minneapolis
GSK Investigational Site, Sioux Falls
GSK Investigational Site, Lille
GSK Investigational Site, Billings
GSK Investigational Site, Zion
GSK Investigational Site, Geneva
GSK Investigational Site, Warrenville
GSK Investigational Site, Clermont-Ferrand
GSK Investigational Site, Strasbourg
GSK Investigational Site, Lyon
GSK Investigational Site, Cholet
GSK Investigational Site, Lyon
GSK Investigational Site, Bron
GSK Investigational Site, Lyon
GSK Investigational Site, Pierre-Bénite
GSK Investigational Site, New Orleans
GSK Investigational Site, Kuopio
GSK Investigational Site, Covington
GSK Investigational Site, Shreveport
GSK Investigational Site, Le Mans
GSK Investigational Site, Oklahoma City
GSK Investigational Site, Paris
GSK Investigational Site, Paris
GSK Investigational Site, Dallas
GSK Investigational Site, Paris
GSK Investigational Site, Saint-Cloud
GSK Investigational Site, Tyler
GSK Investigational Site, Paris
GSK Investigational Site, Paris
GSK Investigational Site, Rehovot
GSK Investigational Site, Fort Worth
GSK Investigational Site, Houston
GSK Investigational Site, The Woodlands
GSK Investigational Site, San Antonio
GSK Investigational Site, Austin
GSK Investigational Site, Lviv
GSK Investigational Site, Napoli
GSK Investigational Site, Ogden
GSK Investigational Site, Avignon
GSK Investigational Site, Phoenix
GSK Investigational Site, Tucson
GSK Investigational Site, Poitiers
GSK Investigational Site, Ravensburg
GSK Investigational Site, Los Angeles
GSK Investigational Site, Los Angeles
GSK Investigational Site, Newport Beach
GSK Investigational Site, Villejuif
GSK Investigational Site, Portland
GSK Investigational Site, Eugene
GSK Investigational Site, Seattle
GSK Investigational Site, Seattle
GSK Investigational Site, Kennewick
GSK Investigational Site, Anchorage
GSK Investigational Site, Craiova
GSK Investigational Site, Minsk
GSK Investigational Site, Timișoara
GSK Investigational Site, Cluj-Napoca
GSK Investigational Site, Cluj-Napoca
GSK Investigational Site, Constanța
GSK Investigational Site, Haifa
GSK Investigational Site, Haifa
GSK Investigational Site, Petah Tikva
GSK Investigational Site, Holon
GSK Investigational Site, Beersheba
GSK Investigational Site, Farmington
GSK Investigational Site, Hartford
GSK Investigational Site, Scarborough
GSK Investigational Site, Boston
GSK Investigational Site, Springfield
GSK Investigational Site, Worcester
GSK Investigational Site, Neptune City
GSK Investigational Site, Teaneck
GSK Investigational Site, Rochester
GSK Investigational Site, Willow Grove
GSK Investigational Site, Providence
GSK Investigational Site, Vancouver
GSK Investigational Site, London
GSK Investigational Site, Toronto
GSK Investigational Site, Montreal
GSK Investigational Site, Montreal
GSK Investigational Site, Sherbrooke
GSK Investigational Site, Prague
GSK Investigational Site, Prague
GSK Investigational Site, Copenhagen
GSK Investigational Site, Helsinki
GSK Investigational Site, Nice
GSK Investigational Site, Athens
GSK Investigational Site, Amsterdam
GSK Investigational Site, Groningen
GSK Investigational Site, Maastricht
GSK Investigational Site, Nijmegen
GSK Investigational Site, Rotterdam
GSK Investigational Site, Utrecht
GSK Investigational Site, Oslo
GSK Investigational Site, Olsztyn
GSK Investigational Site, Szczecin
GSK Investigational Site, Warsaw
GSK Investigational Site, Bucharest
GSK Investigational Site, Ávila
GSK Investigational Site, Badalona
GSK Investigational Site, Barcelona
GSK Investigational Site, Glasgow
GSK Investigational Site, Metropolitan Borough of Wirral
GSK Investigational Site, Portsmouth
GSK Investigational Site, Sutton
GSK Investigational Site, Truro
European Network of Gynaecological Oncological Trial Groups (ENGOT)
OTHER
Tesaro, Inc.
INDUSTRY